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Mutation:
TRA2B R177L
Summary
Isoform:
Position:
177
Ref:
R
Mutation:
L
PTM impact:
network-rewiring
PTM affected:
8
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
HNSC
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 170S
Affected site:
Position: 170
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 167T | RSPS[P/T]PYYSRGGYRSR | 3 |
distal
|
| 171H | RSPSPYYS[R/H]RGGYRSR | 1 |
proximal
|
| 167A | RSPS[P/A]PYYSRGGYRSR | 3 |
distal
|
| 168N | RSPSP[Y/N]YYSRGGYRSR | 2 |
proximal
|
PTM Site: 171R
Affected site:
Position: 171
Residue: R
Type: methylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 167T | SPS[P/T]PYYSRGGYRSRS | 4 |
distal
|
| 171H | SPSPYYS[R/H]RGGYRSRS | 0 |
direct
|
| 177L | SPSPYYSRGGYRS[R/L]RS | 6 |
distal
|
| 167A | SPS[P/A]PYYSRGGYRSRS | 4 |
distal
|
| 168N | SPSP[Y/N]YYSRGGYRSRS | 3 |
distal
|
PTM Site: 176S
Affected site:
Position: 176
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 171H | YS[R/H]RGGYRSRSRSRSY | 5 |
network-rewiring
|
| 177L | YSRGGYRS[R/L]RSRSRSY | 1 |
proximal
|
| 181G | YSRGGYRSRSRS[R/G]RSY | 5 |
distal
|
PTM Site: 178S
Affected site:
Position: 178
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 184P | RGGYRSRSRSRSY[S/P]SP | 6 |
distal
|
| 184L | RGGYRSRSRSRSY[S/L]SP | 6 |
distal
|
| 177L | RGGYRS[R/L]RSRSRSYSP | 1 |
proximal
|
| 181G | RGGYRSRSRS[R/G]RSYSP | 3 |
distal
|
PTM Site: 180S
Affected site:
Position: 180
Residue: S
Type: phosphorylation
Best loss of PTM site:
AKT2 (probability p=0.983)
Site: 180S (phosphorylation)
Position in motif: -3
There are 9 other predicted
losses:
- CHEK1 (p=0.98)
- CAMK2A (p=0.944)
- PRKACA (p=0.925)
- PRKG1 (p=0.895)
- PRKAA1 (p=0.893)
- PRKD1 (p=0.88)
- PAK1 (p=0.874)
- CAMK4 (p=0.869)
- CAMK1 (p=0.855)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 184P | GYRSRSRSRSY[S/P]SPRR | 4 |
distal
|
| 184L | GYRSRSRSRSY[S/L]SPRR | 4 |
distal
|
| 177L | GYRS[R/L]RSRSRSYSPRR | 3 |
network-rewiring
|
| 181G | GYRSRSRS[R/G]RSYSPRR | 1 |
proximal
|
PTM Site: 182S
Affected site:
Position: 182
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 184P | RSRSRSRSY[S/P]SPRRY- | 2 |
proximal
|
| 184L | RSRSRSRSY[S/L]SPRRY- | 2 |
proximal
|
| 177L | RS[R/L]RSRSRSYSPRRY- | 5 |
distal
|
| 181G | RSRSRS[R/G]RSYSPRRY- | 1 |
proximal
|
PTM Site: 183Y
Affected site:
Position: 183
Residue: Y
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 184P | SRSRSRSY[S/P]SPRRY-- | 1 |
proximal
|
| 184L | SRSRSRSY[S/L]SPRRY-- | 1 |
proximal
|
| 177L | S[R/L]RSRSRSYSPRRY-- | 6 |
distal
|
| 181G | SRSRS[R/G]RSYSPRRY-- | 2 |
proximal
|
PTM Site: 184S
Affected site:
Position: 184
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 184P | RSRSRSY[S/P]SPRRY--- | 0 |
direct
|
| 184L | RSRSRSY[S/L]SPRRY--- | 0 |
direct
|
| 181G | RSRS[R/G]RSYSPRRY--- | 3 |
network-rewiring
|
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