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Mutation:
STX10 R147C
Summary
Isoform:
Position:
147
Ref:
R
Mutation:
C
PTM impact:
network-rewiring
PTM affected:
4
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
[0.09984029999999999]
PTM Site: 140S
Affected site:
Position: 140
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 142I | PSDLLDASA[V/I]VSATSR | 2 |
proximal
|
| 141T | PSDLLDAS[A/T]AVSATSR | 1 |
proximal
|
| 134R | P[S/R]SDLLDASAVSATSR | 6 |
distal
|
| 143L | PSDLLDASAV[S/L]SATSR | 3 |
network-rewiring
|
PTM Site: 143S
Affected site:
Position: 143
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 142I | LLDASA[V/I]VSATSRYIE | 1 |
proximal
|
| 141T | LLDAS[A/T]AVSATSRYIE | 2 |
proximal
|
| 149M | LLDASAVSATSRY[I/M]IE | 6 |
distal
|
| 147C | LLDASAVSATS[R/C]RYIE | 4 |
distal
|
| 143L | LLDASAV[S/L]SATSRYIE | 0 |
direct
|
PTM Site: 145T
Affected site:
Position: 145
Residue: T
Type: phosphorylation
Best loss of PTM site:
PRKCG (probability p=0.974)
Site: 145T (phosphorylation)
Position in motif: 2
There are 3 other predicted
losses:
- PRKCA (p=0.971)
- PRKCB (p=0.965)
- PRKCE (p=0.94)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 142I | DASA[V/I]VSATSRYIEEQ | 3 |
distal
|
| 141T | DAS[A/T]AVSATSRYIEEQ | 4 |
distal
|
| 149M | DASAVSATSRY[I/M]IEEQ | 4 |
distal
|
| 147C | DASAVSATS[R/C]RYIEEQ | 2 |
network-rewiring
|
| 143L | DASAV[S/L]SATSRYIEEQ | 2 |
proximal
|
PTM Site: 146S
Affected site:
Position: 146
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 142I | ASA[V/I]VSATSRYIEEQQ | 4 |
distal
|
| 141T | AS[A/T]AVSATSRYIEEQQ | 5 |
distal
|
| 149M | ASAVSATSRY[I/M]IEEQQ | 3 |
distal
|
| 147C | ASAVSATS[R/C]RYIEEQQ | 1 |
proximal
|
| 143L | ASAV[S/L]SATSRYIEEQQ | 3 |
distal
|
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