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Summary

Isoform:
Position:
56
Ref:
S
Mutation:
N
PTM impact:
direct
PTM affected:
5
Kinases:
AURKB, AURORA A, AURKB, AURKA, PAK4, SRC

Clinical Information

Cancer types: (TCGA MC3)

COAD, LIHC

Cancer types: (PCAWG)

Biliary-AdenoCA, Panc-AdenoCA

Disease Annotations: (ClinVar)

Hereditary cancer-predisposing syndrome, Li-Fraumeni syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 50R

Affected site:

Position: 50
Residue: R
Type: methylation

Impact:

distal

Other known mutations affecting this site

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Mutation
In sequence
Distance
Impact
50K RVEYLDD[R/K]RNTFRHSV 0
direct
50G RVEYLDD[R/G]RNTFRHSV 0
direct
51Y RVEYLDDR[N/Y]NTFRHSV 1
proximal
49G RVEYLD[D/G]DRNTFRHSV 1
proximal
49H RVEYLD[D/H]DRNTFRHSV 1
proximal
Showing 1 to 5 of 39 rows

PTM Site: 52T

Affected site:

Position: 52
Residue: T
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

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Mutation
In sequence
Distance
Impact
52A EYLDDRN[T/A]TFRHSVVV 0
direct
52P EYLDDRN[T/P]TFRHSVVV 0
direct
52I EYLDDRN[T/I]TFRHSVVV 0
direct
53I EYLDDRNT[F/I]FRHSVVV 1
proximal
51Y EYLDDR[N/Y]NTFRHSVVV 1
proximal
Showing 1 to 5 of 39 rows

PTM Site: 54R

Affected site:

Position: 54
Residue: R
Type: methylation

Impact:

proximal

Other known mutations affecting this site

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Mutation
In sequence
Distance
Impact
54L LDDRNTF[R/L]RHSVVVPY 0
direct
54P LDDRNTF[R/P]RHSVVVPY 0
direct
54Q LDDRNTF[R/Q]RHSVVVPY 0
direct
54G LDDRNTF[R/G]RHSVVVPY 0
direct
55Q LDDRNTFR[H/Q]HSVVVPY 1
proximal
Showing 1 to 5 of 38 rows

PTM Site: 56S

Affected site:

Position: 56
Residue: S
Type: phosphorylation

Impact:

direct

Other known mutations affecting this site

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Mutation
In sequence
Distance
Impact
56R DRNTFRH[S/R]SVVVPYEP 0
direct
56I DRNTFRH[S/I]SVVVPYEP 0
direct
56T DRNTFRH[S/T]SVVVPYEP 0
direct
56N DRNTFRH[S/N]SVVVPYEP 0
direct
56G DRNTFRH[S/G]SVVVPYEP 0
direct
Showing 1 to 5 of 41 rows

PTM Site: 61Y

Affected site:

Position: 61
Residue: Y
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

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Mutation
In sequence
Distance
Impact
61C RHSVVVP[Y/C]YEPPEVGS 0
direct
61S RHSVVVP[Y/S]YEPPEVGS 0
direct
61D RHSVVVP[Y/D]YEPPEVGS 0
direct
61H RHSVVVP[Y/H]YEPPEVGS 0
direct
61N RHSVVVP[Y/N]YEPPEVGS 0
direct
Showing 1 to 5 of 42 rows

External references

dbSNP:

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