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Mutation:
TP53 S56N
Summary
Isoform:
Position:
56
Ref:
S
Mutation:
N
PTM impact:
direct
PTM affected:
5
Kinases:
AURKB,
AURORA A,
AURKB,
AURKA,
PAK4,
SRC
Clinical Information
Cancer types: (TCGA MC3)
COAD, LIHC
Cancer types: (PCAWG)
Biliary-AdenoCA, Panc-AdenoCA
Disease Annotations: (ClinVar)
Hereditary cancer-predisposing syndrome, Li-Fraumeni syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 50R
Affected site:
Position: 50
Residue: R
Type: methylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
---|---|---|---|
50K | RVEYLDD[R/K]RNTFRHSV | 0 |
direct
|
50G | RVEYLDD[R/G]RNTFRHSV | 0 |
direct
|
51Y | RVEYLDDR[N/Y]NTFRHSV | 1 |
proximal
|
49G | RVEYLD[D/G]DRNTFRHSV | 1 |
proximal
|
49H | RVEYLD[D/H]DRNTFRHSV | 1 |
proximal
|
PTM Site: 52T
Affected site:
Position: 52
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
---|---|---|---|
52A | EYLDDRN[T/A]TFRHSVVV | 0 |
direct
|
52P | EYLDDRN[T/P]TFRHSVVV | 0 |
direct
|
52I | EYLDDRN[T/I]TFRHSVVV | 0 |
direct
|
53I | EYLDDRNT[F/I]FRHSVVV | 1 |
proximal
|
51Y | EYLDDR[N/Y]NTFRHSVVV | 1 |
proximal
|
PTM Site: 54R
Affected site:
Position: 54
Residue: R
Type: methylation
Impact:
proximalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
---|---|---|---|
54L | LDDRNTF[R/L]RHSVVVPY | 0 |
direct
|
54P | LDDRNTF[R/P]RHSVVVPY | 0 |
direct
|
54Q | LDDRNTF[R/Q]RHSVVVPY | 0 |
direct
|
54G | LDDRNTF[R/G]RHSVVVPY | 0 |
direct
|
55Q | LDDRNTFR[H/Q]HSVVVPY | 1 |
proximal
|
PTM Site: 56S
Affected site:
Position: 56
Residue: S
Type: phosphorylation
Impact:
directOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
---|---|---|---|
56R | DRNTFRH[S/R]SVVVPYEP | 0 |
direct
|
56I | DRNTFRH[S/I]SVVVPYEP | 0 |
direct
|
56T | DRNTFRH[S/T]SVVVPYEP | 0 |
direct
|
56N | DRNTFRH[S/N]SVVVPYEP | 0 |
direct
|
56G | DRNTFRH[S/G]SVVVPYEP | 0 |
direct
|
PTM Site: 61Y
Affected site:
Position: 61
Residue: Y
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
---|---|---|---|
61C | RHSVVVP[Y/C]YEPPEVGS | 0 |
direct
|
61S | RHSVVVP[Y/S]YEPPEVGS | 0 |
direct
|
61D | RHSVVVP[Y/D]YEPPEVGS | 0 |
direct
|
61H | RHSVVVP[Y/H]YEPPEVGS | 0 |
direct
|
61N | RHSVVVP[Y/N]YEPPEVGS | 0 |
direct
|
External references
dbSNP:
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