TP53 Y61C

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Mutation:

Summary

Isoform:

NM_001276698

Position:

Ref:

Mutation:

PTM impact:

direct

PTM affected:

Kinases:

PAK4, AURORA A, AURKB, AURKA, SRC

Clinical Information

Cancer types: (TCGA MC3)

GBM, LUSC, OV, PAAD, LUAD, BRCA, UCEC, BLCA, STAD, LGG, HNSC, LIHC, COAD, SKCM, ESCA, KICH, SARC

Cancer types: (PCAWG)

Lung-AdenoCA, Bladder-TCC, Panc-AdenoCA, Ovary-AdenoCA, Liver-HCC, Lymph-CLL, Uterus-AdenoCA, Lung-SCC, Eso-AdenoCa, Breast-AdenoCa

Disease Annotations: (ClinVar)

Li-Fraumeni syndrome, Hereditary cancer-predisposing syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 54R

Affected site:

Position: 54

Residue: R

Type: methylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
60L	LDDRNTFRHSVVV[P/L]PY	6	distal
60R	LDDRNTFRHSVVV[P/R]PY	6	distal
60S	LDDRNTFRHSVVV[P/S]PY	6	distal
59G	LDDRNTFRHSVV[V/G]VPY	5	distal
59M	LDDRNTFRHSVV[V/M]VPY	5	distal
58M	LDDRNTFRHSV[V/M]VVPY	4	distal
57G	LDDRNTFRHS[V/G]VVVPY	3	distal
57E	LDDRNTFRHS[V/E]VVVPY	3	distal
57L	LDDRNTFRHS[V/L]VVVPY	3	distal
57M	LDDRNTFRHS[V/M]VVVPY	3	distal
56R	LDDRNTFRH[S/R]SVVVPY	2	proximal
56I	LDDRNTFRH[S/I]SVVVPY	2	proximal
56T	LDDRNTFRH[S/T]SVVVPY	2	proximal
56N	LDDRNTFRH[S/N]SVVVPY	2	proximal
56G	LDDRNTFRH[S/G]SVVVPY	2	proximal
55Q	LDDRNTFR[H/Q]HSVVVPY	1	proximal
55L	LDDRNTFR[H/L]HSVVVPY	1	proximal
55R	LDDRNTFR[H/R]HSVVVPY	1	proximal
55P	LDDRNTFR[H/P]HSVVVPY	1	proximal
55N	LDDRNTFR[H/N]HSVVVPY	1	proximal
54L	LDDRNTF[R/L]RHSVVVPY	0	direct
54P	LDDRNTF[R/P]RHSVVVPY	0	direct
54Q	LDDRNTF[R/Q]RHSVVVPY	0	direct
54G	LDDRNTF[R/G]RHSVVVPY	0	direct
53I	LDDRNT[F/I]FRHSVVVPY	1	proximal
52A	LDDRN[T/A]TFRHSVVVPY	2	proximal
52P	LDDRN[T/P]TFRHSVVVPY	2	proximal
51Y	LDDR[N/Y]NTFRHSVVVPY	3	distal
50K	LDD[R/K]RNTFRHSVVVPY	4	distal
50G	LDD[R/G]RNTFRHSVVVPY	4	distal
49G	LD[D/G]DRNTFRHSVVVPY	5	distal
49H	LD[D/H]DRNTFRHSVVVPY	5	distal
48H	L[D/H]DDRNTFRHSVVVPY	6	distal
52I	LDDRN[T/I]TFRHSVVVPY	2	proximal
49N	LD[D/N]DRNTFRHSVVVPY	5	distal
59E	LDDRNTFRHSVV[V/E]VPY	5	distal
53V	LDDRNT[F/V]FRHSVVVPY	1	proximal
58G	LDDRNTFRHSV[V/G]VVPY	4	distal

PTM Site: 56S

Affected site:

Position: 56

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
62A	DRNTFRHSVVVPY[E/A]EP	6	distal
62K	DRNTFRHSVVVPY[E/K]EP	6	distal
61C	DRNTFRHSVVVP[Y/C]YEP	5	distal
61S	DRNTFRHSVVVP[Y/S]YEP	5	distal
61D	DRNTFRHSVVVP[Y/D]YEP	5	distal
61H	DRNTFRHSVVVP[Y/H]YEP	5	distal
61N	DRNTFRHSVVVP[Y/N]YEP	5	distal
60L	DRNTFRHSVVV[P/L]PYEP	4	distal
60R	DRNTFRHSVVV[P/R]PYEP	4	distal
60S	DRNTFRHSVVV[P/S]PYEP	4	distal
59G	DRNTFRHSVV[V/G]VPYEP	3	distal
59M	DRNTFRHSVV[V/M]VPYEP	3	distal
58M	DRNTFRHSV[V/M]VVPYEP	2	proximal
57G	DRNTFRHS[V/G]VVVPYEP	1	proximal
57E	DRNTFRHS[V/E]VVVPYEP	1	proximal
57L	DRNTFRHS[V/L]VVVPYEP	1	proximal
57M	DRNTFRHS[V/M]VVVPYEP	1	proximal
56R	DRNTFRH[S/R]SVVVPYEP	0	direct
56I	DRNTFRH[S/I]SVVVPYEP	0	direct
56T	DRNTFRH[S/T]SVVVPYEP	0	direct
56N	DRNTFRH[S/N]SVVVPYEP	0	direct
56G	DRNTFRH[S/G]SVVVPYEP	0	direct
55Q	DRNTFR[H/Q]HSVVVPYEP	1	proximal
55L	DRNTFR[H/L]HSVVVPYEP	1	proximal
55R	DRNTFR[H/R]HSVVVPYEP	1	proximal
55P	DRNTFR[H/P]HSVVVPYEP	1	proximal
55N	DRNTFR[H/N]HSVVVPYEP	1	proximal
54L	DRNTF[R/L]RHSVVVPYEP	2	network-rewiring
54P	DRNTF[R/P]RHSVVVPYEP	2	network-rewiring
54Q	DRNTF[R/Q]RHSVVVPYEP	2	network-rewiring
54G	DRNTF[R/G]RHSVVVPYEP	2	network-rewiring
53I	DRNT[F/I]FRHSVVVPYEP	3	distal
52A	DRN[T/A]TFRHSVVVPYEP	4	distal
52P	DRN[T/P]TFRHSVVVPYEP	4	distal
51Y	DR[N/Y]NTFRHSVVVPYEP	5	distal
50K	D[R/K]RNTFRHSVVVPYEP	6	distal
50G	D[R/G]RNTFRHSVVVPYEP	6	distal
52I	DRN[T/I]TFRHSVVVPYEP	4	distal
59E	DRNTFRHSVV[V/E]VPYEP	3	distal
53V	DRNT[F/V]FRHSVVVPYEP	3	distal
58G	DRNTFRHSV[V/G]VVPYEP	2	proximal

PTM Site: 61Y

Affected site:

Position: 61

Residue: Y

Type: phosphorylation

Impact:

direct

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
67V	RHSVVVPYEPPEV[G/V]GS	6	distal
67A	RHSVVVPYEPPEV[G/A]GS	6	distal
67S	RHSVVVPYEPPEV[G/S]GS	6	distal
66D	RHSVVVPYEPPE[V/D]VGS	5	distal
66I	RHSVVVPYEPPE[V/I]VGS	5	distal
65G	RHSVVVPYEPP[E/G]EVGS	4	distal
65A	RHSVVVPYEPP[E/A]EVGS	4	distal
65K	RHSVVVPYEPP[E/K]EVGS	4	distal
64L	RHSVVVPYEP[P/L]PEVGS	3	network-rewiring
63L	RHSVVVPYE[P/L]PPEVGS	2	proximal
63S	RHSVVVPYE[P/S]PPEVGS	2	proximal
62A	RHSVVVPY[E/A]EPPEVGS	1	proximal
62K	RHSVVVPY[E/K]EPPEVGS	1	proximal
61C	RHSVVVP[Y/C]YEPPEVGS	0	direct
61S	RHSVVVP[Y/S]YEPPEVGS	0	direct
61D	RHSVVVP[Y/D]YEPPEVGS	0	direct
61H	RHSVVVP[Y/H]YEPPEVGS	0	direct
61N	RHSVVVP[Y/N]YEPPEVGS	0	direct
60L	RHSVVV[P/L]PYEPPEVGS	1	proximal
60R	RHSVVV[P/R]PYEPPEVGS	1	proximal
60S	RHSVVV[P/S]PYEPPEVGS	1	proximal
59G	RHSVV[V/G]VPYEPPEVGS	2	proximal
59M	RHSVV[V/M]VPYEPPEVGS	2	proximal
58M	RHSV[V/M]VVPYEPPEVGS	3	distal
57G	RHS[V/G]VVVPYEPPEVGS	4	distal
57E	RHS[V/E]VVVPYEPPEVGS	4	distal
57L	RHS[V/L]VVVPYEPPEVGS	4	distal
57M	RHS[V/M]VVVPYEPPEVGS	4	distal
56R	RH[S/R]SVVVPYEPPEVGS	5	distal
56I	RH[S/I]SVVVPYEPPEVGS	5	distal
56T	RH[S/T]SVVVPYEPPEVGS	5	distal
56N	RH[S/N]SVVVPYEPPEVGS	5	distal
56G	RH[S/G]SVVVPYEPPEVGS	5	distal
55Q	R[H/Q]HSVVVPYEPPEVGS	6	distal
55L	R[H/L]HSVVVPYEPPEVGS	6	distal
55R	R[H/R]HSVVVPYEPPEVGS	6	distal
55P	R[H/P]HSVVVPYEPPEVGS	6	distal
55N	R[H/N]HSVVVPYEPPEVGS	6	distal
64H	RHSVVVPYEP[P/H]PEVGS	3	network-rewiring
65D	RHSVVVPYEPP[E/D]EVGS	4	distal
59E	RHSVV[V/E]VPYEPPEVGS	2	proximal
58G	RHSV[V/G]VVPYEPPEVGS	3	distal

External references

dbSNP:

rs121912666

If you have any questions or feedback about this mutation: