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Mutation:
TP53 Y61H
Summary
Isoform:
Position:
61
Ref:
Y
Mutation:
H
PTM impact:
direct
PTM affected:
3
Kinases:
AURKA,
AURORA A,
PAK4,
AURKB,
SRC
Clinical Information
Cancer types: (TCGA MC3)
BRCA, LGG, SARC, CESC
Cancer types: (PCAWG)
Breast-AdenoCa
Disease Annotations: (ClinVar)
Hereditary cancer-predisposing syndrome, Li-Fraumeni syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
[0.0199681]
PTM Site: 54R
Affected site:
Position: 54
Residue: R
Type: methylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 54L | LDDRNTF[R/L]RHSVVVPY | 0 |
direct
|
| 54P | LDDRNTF[R/P]RHSVVVPY | 0 |
direct
|
| 54Q | LDDRNTF[R/Q]RHSVVVPY | 0 |
direct
|
| 54G | LDDRNTF[R/G]RHSVVVPY | 0 |
direct
|
| 55Q | LDDRNTFR[H/Q]HSVVVPY | 1 |
proximal
|
PTM Site: 56S
Affected site:
Position: 56
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 56R | DRNTFRH[S/R]SVVVPYEP | 0 |
direct
|
| 56I | DRNTFRH[S/I]SVVVPYEP | 0 |
direct
|
| 56T | DRNTFRH[S/T]SVVVPYEP | 0 |
direct
|
| 56N | DRNTFRH[S/N]SVVVPYEP | 0 |
direct
|
| 56G | DRNTFRH[S/G]SVVVPYEP | 0 |
direct
|
PTM Site: 61Y
Affected site:
Position: 61
Residue: Y
Type: phosphorylation
Impact:
directOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 61C | RHSVVVP[Y/C]YEPPEVGS | 0 |
direct
|
| 61S | RHSVVVP[Y/S]YEPPEVGS | 0 |
direct
|
| 61D | RHSVVVP[Y/D]YEPPEVGS | 0 |
direct
|
| 61H | RHSVVVP[Y/H]YEPPEVGS | 0 |
direct
|
| 61N | RHSVVVP[Y/N]YEPPEVGS | 0 |
direct
|
External references
dbSNP:
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