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Mutation:
SORBS2 R374Q
Summary
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
[0.0077]
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 370T
Affected site:
Position: 370
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 374Q | GDQSASRTSPG[R/Q]RVDL | 4 |
distal
|
| 368R | GDQSA[S/R]SRTSPGRVDL | 2 |
network-rewiring
|
| 367V | GDQS[A/V]ASRTSPGRVDL | 3 |
distal
|
| 368N | GDQSA[S/N]SRTSPGRVDL | 2 |
proximal
|
| 366N | GDQ[S/N]SASRTSPGRVDL | 4 |
distal
|
PTM Site: 371S
Affected site:
Position: 371
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 374Q | DQSASRTSPG[R/Q]RVDLP | 3 |
distal
|
| 368R | DQSA[S/R]SRTSPGRVDLP | 3 |
network-rewiring
|
| 367V | DQS[A/V]ASRTSPGRVDLP | 4 |
distal
|
| 368N | DQSA[S/N]SRTSPGRVDLP | 3 |
distal
|
| 366N | DQ[S/N]SASRTSPGRVDLP | 5 |
distal
|
PTM Site: 380S
Affected site:
Position: 380
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 374Q | G[R/Q]RVDLPGSSTTLTKS | 6 |
distal
|
| 380L | GRVDLPG[S/L]SSTTLTKS | 0 |
direct
|
| 379E | GRVDLP[G/E]GSSTTLTKS | 1 |
proximal
|
PTM Site: 381S
Affected site:
Position: 381
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 380L | RVDLPG[S/L]SSTTLTKSF | 1 |
proximal
|
| 379E | RVDLP[G/E]GSSTTLTKSF | 2 |
network-rewiring
|
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