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Mutation:
SORBS2 G379E
Summary
Isoform:
Position:
379
Ref:
G
Mutation:
E
PTM impact:
network-rewiring
PTM affected:
3
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
SKCM
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 380S
Affected site:
Position: 380
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 374Q | G[R/Q]RVDLPGSSTTLTKS | 6 |
distal
|
| 380L | GRVDLPG[S/L]SSTTLTKS | 0 |
direct
|
| 379E | GRVDLP[G/E]GSSTTLTKS | 1 |
proximal
|
PTM Site: 381S
Affected site:
Position: 381
Residue: S
Type: phosphorylation
Only gain of PTM site:
PLK1 (probability p=0.888)
Site: 381S (phosphorylation)
Position in motif: -2
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 380L | RVDLPG[S/L]SSTTLTKSF | 1 |
proximal
|
| 379E | RVDLP[G/E]GSSTTLTKSF | 2 |
network-rewiring
|
PTM Site: 385T
Affected site:
Position: 385
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 380L | PG[S/L]SSTTLTKSFTSSS | 5 |
distal
|
| 379E | P[G/E]GSSTTLTKSFTSSS | 6 |
distal
|
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