You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
PKMYT1 E157K
Summary
Isoform:
Position:
157
Ref:
E
Mutation:
K
PTM impact:
network-rewiring
PTM affected:
3
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
[0.0199681]
PTM Site: 154K
Affected site:
Position: 154
Residue: K
Type: ubiquitination
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 153P | GPKDRA[R/P]RKLAEVGSH | 1 |
proximal
|
| 153C | GPKDRA[R/C]RKLAEVGSH | 1 |
proximal
|
| 151Q | GPKD[R/Q]RARKLAEVGSH | 3 |
distal
|
| 157K | GPKDRARKLA[E/K]EVGSH | 3 |
distal
|
| 152S | GPKDR[A/S]ARKLAEVGSH | 2 |
proximal
|
| 151W | GPKD[R/W]RARKLAEVGSH | 3 |
distal
|
| 156V | GPKDRARKL[A/V]AEVGSH | 2 |
proximal
|
| 154Q | GPKDRAR[K/Q]KLAEVGSH | 0 |
direct
|
PTM Site: 160S
Affected site:
Position: 160
Residue: S
Type: phosphorylation
Best gain of PTM site:
CHEK1 (probability p=0.946)
Site: 160S (phosphorylation)
Position in motif: -3
There is 1 other predicted
gain:
- PAK1 (p=0.9)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 157K | RKLA[E/K]EVGSHEKVGQH | 3 |
network-rewiring
|
| 156V | RKL[A/V]AEVGSHEKVGQH | 4 |
distal
|
| 154Q | R[K/Q]KLAEVGSHEKVGQH | 6 |
distal
|
PTM Site: 163K
Affected site:
Position: 163
Residue: K
Type: ubiquitination
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 157K | A[E/K]EVGSHEKVGQHPCC | 6 |
distal
|
If you have any questions or feedback about this mutation:
Contact us