PKMYT1 R153C

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Mutation:

Summary

Isoform:

NM_004203

Position:

153

Ref:

Mutation:

PTM impact:

proximal

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

[0.0078]

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 149K

Affected site:

Position: 149

Residue: K

Type: ubiquitination

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
153P	MSPFRGPKDRA[R/P]RKLA	4	distal
153C	MSPFRGPKDRA[R/C]RKLA	4	distal
151Q	MSPFRGPKD[R/Q]RARKLA	2	proximal
146Q	MSPF[R/Q]RGPKDRARKLA	3	distal
152S	MSPFRGPKDR[A/S]ARKLA	3	distal
151W	MSPFRGPKD[R/W]RARKLA	2	proximal
154Q	MSPFRGPKDRAR[K/Q]KLA	5	distal

PTM Site: 154K

Affected site:

Position: 154

Residue: K

Type: ubiquitination

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
153P	GPKDRA[R/P]RKLAEVGSH	1	proximal
153C	GPKDRA[R/C]RKLAEVGSH	1	proximal
151Q	GPKD[R/Q]RARKLAEVGSH	3	distal
157K	GPKDRARKLA[E/K]EVGSH	3	distal
152S	GPKDR[A/S]ARKLAEVGSH	2	proximal
151W	GPKD[R/W]RARKLAEVGSH	3	distal
156V	GPKDRARKL[A/V]AEVGSH	2	proximal
154Q	GPKDRAR[K/Q]KLAEVGSH	0	direct

PTM Site: 160S

Affected site:

Position: 160

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
157K	RKLA[E/K]EVGSHEKVGQH	3	network-rewiring
156V	RKL[A/V]AEVGSHEKVGQH	4	distal
154Q	R[K/Q]KLAEVGSHEKVGQH	6	distal

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