FMNL1 K682R

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Mutation:

Summary

Isoform:

NM_005892

Position:

682

Ref:

Mutation:

PTM impact:

direct

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

[0.0199681]

PTM Site: 675S

Affected site:

Position: 675

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
681L	VLQELDMSDFEEQ[F/L]FK	6	distal

PTM Site: 682K

Affected site:

Position: 682

Residue: K

Type: ubiquitination

Impact:

direct

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
682R	SDFEEQF[K/R]KTKSQGPS	0	direct
681L	SDFEEQ[F/L]FKTKSQGPS	1	proximal

PTM Site: 684K

Affected site:

Position: 684

Residue: K

Type: ubiquitination

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
682R	FEEQF[K/R]KTKSQGPSLD	2	proximal
681L	FEEQ[F/L]FKTKSQGPSLD	3	distal

PTM Site: 685S

Affected site:

Position: 685

Residue: S

Type: phosphorylation

Best gain of PTM site:

AKT1 (probability p=0.975)

Site: 685S (phosphorylation)

Position in motif: -3

There are 5 other predicted gains:

CHEK2 (p=0.932)
RPS6KB1 (p=0.907)
PRKACA (p=0.892)
PRKCD (p=0.874)
CAMK2A (p=0.86)

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
682R	EEQF[K/R]KTKSQGPSLDL	3	network-rewiring
681L	EEQ[F/L]FKTKSQGPSLDL	4	distal

PTM Site: 689S

Affected site:

Position: 689

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
692F	KTKSQGPSLD[L/F]LSALK	3	distal
694T	KTKSQGPSLDLS[A/T]ALK	5	distal

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