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Mutation:
TRIM29 P22T
Summary
Isoform:
Position:
22
Ref:
P
Mutation:
T
PTM impact:
network-rewiring
PTM affected:
4
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
[0.0199681]
PTM Site: 21S
Affected site:
Position: 21
Residue: S
Type: phosphorylation
Best loss of PTM site:
MAPK10 (probability p=0.99)
Site: 21S (phosphorylation)
Position in motif: 1
There are 10 other predicted
losses:
- MAPK3 (p=0.953)
- MAPK1 (p=0.948)
- MAPK14 (p=0.944)
- MTOR (p=0.93)
- GSK3B (p=0.921)
- CDK1 (p=0.921)
- CDK5 (p=0.895)
- MAPK7 (p=0.885)
- CDK2 (p=0.882)
- MAPK9 (p=0.864)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 22T | PEARDARS[P/T]PSGPSGS | 1 |
network-rewiring
|
| 20G | PEARDA[R/G]RSPSGPSGS | 1 |
proximal
|
| 26N | PEARDARSPSGP[S/N]SGS | 5 |
distal
|
| 23L | PEARDARSP[S/L]SGPSGS | 2 |
proximal
|
PTM Site: 23S
Affected site:
Position: 23
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 22T | ARDARS[P/T]PSGPSGSLE | 1 |
proximal
|
| 20G | ARDA[R/G]RSPSGPSGSLE | 3 |
network-rewiring
|
| 26N | ARDARSPSGP[S/N]SGSLE | 3 |
distal
|
| 23L | ARDARSP[S/L]SGPSGSLE | 0 |
direct
|
PTM Site: 26S
Affected site:
Position: 26
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 30K | ARSPSGPSGSL[E/K]ENGT | 4 |
distal
|
| 22T | ARS[P/T]PSGPSGSLENGT | 4 |
distal
|
| 20G | A[R/G]RSPSGPSGSLENGT | 6 |
distal
|
| 26N | ARSPSGP[S/N]SGSLENGT | 0 |
direct
|
| 23L | ARSP[S/L]SGPSGSLENGT | 3 |
distal
|
PTM Site: 28S
Affected site:
Position: 28
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 30K | SPSGPSGSL[E/K]ENGTKA | 2 |
network-rewiring
|
| 22T | S[P/T]PSGPSGSLENGTKA | 6 |
distal
|
| 26N | SPSGP[S/N]SGSLENGTKA | 2 |
proximal
|
| 23L | SP[S/L]SGPSGSLENGTKA | 5 |
distal
|
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