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You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:

TRIM29 R20G

Summary

Isoform:
NM_012101
Position:
20
Ref:
R
Mutation:
G
PTM impact:
network-rewiring
PTM affected:
4
Kinases:

Clinical Information

Cancer types: (TCGA MC3)

LUSC

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 13S

Affected site:

Position: 13
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
11R ASRSN[G/R]GSSPEARDAR 2
network-rewiring
7P A[S/P]SRSNGSSPEARDAR 6
distal

PTM Site: 21S

Affected site:

Position: 21
Residue: S
Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation In sequence Distance Impact
22T PEARDARS[P/T]PSGPSGS 1
network-rewiring
20G PEARDA[R/G]RSPSGPSGS 1
proximal
26N PEARDARSPSGP[S/N]SGS 5
distal
23L PEARDARSP[S/L]SGPSGS 2
proximal

PTM Site: 23S

Affected site:

Position: 23
Residue: S
Type: phosphorylation

Best loss of PTM site:

AKT1 (probability p=0.99)
Site: 23S (phosphorylation)
Position in motif: -3
There are 10 other predicted losses:
  • PAK1 (p=0.966)
  • CHEK1 (p=0.965)
  • RPS6KA1 (p=0.959)
  • PRKACA (p=0.923)
  • PRKAA1 (p=0.91)
  • CAMK2A (p=0.888)
  • SGK1 (p=0.882)
  • PRKD1 (p=0.873)
  • RPS6KB1 (p=0.865)
  • CAMK1 (p=0.86)

Other known mutations affecting this site

Mutation In sequence Distance Impact
22T ARDARS[P/T]PSGPSGSLE 1
proximal
20G ARDA[R/G]RSPSGPSGSLE 3
network-rewiring
26N ARDARSPSGP[S/N]SGSLE 3
distal
23L ARDARSP[S/L]SGPSGSLE 0
direct

PTM Site: 26S

Affected site:

Position: 26
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
30K ARSPSGPSGSL[E/K]ENGT 4
distal
22T ARS[P/T]PSGPSGSLENGT 4
distal
20G A[R/G]RSPSGPSGSLENGT 6
distal
26N ARSPSGP[S/N]SGSLENGT 0
direct
23L ARSP[S/L]SGPSGSLENGT 3
distal

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