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You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:

TRIM29 E30K

Summary

Isoform:
NM_012101
Position:
30
Ref:
E
Mutation:
K
PTM impact:
network-rewiring
PTM affected:
4
Kinases:

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

[0.0077]

Minor Allele Frequency: (1000 Genomes)

[0.0199681]

PTM Site: 23S

Affected site:

Position: 23
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
22T ARDARS[P/T]PSGPSGSLE 1
proximal
20G ARDA[R/G]RSPSGPSGSLE 3
network-rewiring
26N ARDARSPSGP[S/N]SGSLE 3
distal
23L ARDARSP[S/L]SGPSGSLE 0
direct

PTM Site: 26S

Affected site:

Position: 26
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
30K ARSPSGPSGSL[E/K]ENGT 4
distal
22T ARS[P/T]PSGPSGSLENGT 4
distal
20G A[R/G]RSPSGPSGSLENGT 6
distal
26N ARSPSGP[S/N]SGSLENGT 0
direct
23L ARSP[S/L]SGPSGSLENGT 3
distal

PTM Site: 28S

Affected site:

Position: 28
Residue: S
Type: phosphorylation

Best gain of PTM site:

PRKCA (probability p=0.943)
Site: 28S (phosphorylation)
Position in motif: 2
There are 3 other predicted gains:
  • PAK1 (p=0.914)
  • PRKCB (p=0.862)
  • PRKCG (p=0.855)

Other known mutations affecting this site

Mutation In sequence Distance Impact
30K SPSGPSGSL[E/K]ENGTKA 2
network-rewiring
22T S[P/T]PSGPSGSLENGTKA 6
distal
26N SPSGP[S/N]SGSLENGTKA 2
proximal
23L SP[S/L]SGPSGSLENGTKA 5
distal

PTM Site: 33T

Affected site:

Position: 33
Residue: T
Type: phosphorylation

Best gain of PTM site:

PRKCA (probability p=0.943)
Site: 28S (phosphorylation)
Position in motif: 2
There are 3 other predicted gains:
  • PAK1 (p=0.914)
  • PRKCB (p=0.862)
  • PRKCG (p=0.855)

Other known mutations affecting this site

Mutation In sequence Distance Impact
30K SGSL[E/K]ENGTKADGKDA 3
network-rewiring
39N SGSLENGTKADGK[D/N]DA 6
distal

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