GMIP P419L

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Mutation:

Summary

Isoform:

NM_016573

Position:

419

Ref:

Mutation:

PTM impact:

network-rewiring

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

[0.0231]

Minor Allele Frequency: (1000 Genomes)

[0.17971199999999998]

PTM Site: 414T

Affected site:

Position: 414

Residue: T

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
419L	TGWRWQGTPGPT[P/L]PGS	5	distal
410H	TGW[R/H]RWQGTPGPTPGS	4	distal

PTM Site: 418T

Affected site:

Position: 418

Residue: T

Type: phosphorylation

Only gain of PTM site:

PRKDC (probability p=0.978)

Site: 418T (phosphorylation)

Position in motif: 1

Best loss of PTM site:

MAPK1 (probability p=0.947)

Site: 418T (phosphorylation)

Position in motif: 1

There are 8 other predicted losses:

MAPK3 (p=0.944)
MAPK14 (p=0.939)
CDK1 (p=0.921)
MAPK8 (p=0.912)
GSK3B (p=0.911)
HIPK2 (p=0.899)
CDK2 (p=0.895)
CDK5 (p=0.851)

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
419L	WQGTPGPT[P/L]PGSDVDS	1	network-rewiring

PTM Site: 421S

Affected site:

Position: 421

Residue: S

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
426M	TPGPTPGSDVDS[V/M]VGG	5	distal
419L	TPGPT[P/L]PGSDVDSVGG	2	proximal

PTM Site: 425S

Affected site:

Position: 425

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
431Q	TPGSDVDSVGGGS[E/Q]ES	6	distal
426M	TPGSDVDS[V/M]VGGGSES	1	proximal
419L	T[P/L]PGSDVDSVGGGSES	6	distal
429C	TPGSDVDSVGG[G/C]GSES	4	distal

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