G2E3 Q326L

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Mutation:

Summary

Isoform:

NM_017769

Position:

326

Ref:

Mutation:

PTM impact:

proximal

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

KIRC

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 320S

Affected site:

Position: 320

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
321T	DCLLEESS[P/T]PKLPRQS	1	network-rewiring
321L	DCLLEESS[P/L]PKLPRQS	1	network-rewiring
322E	DCLLEESSP[K/E]KLPRQS	2	proximal
326L	DCLLEESSPKLPR[Q/L]QS	6	distal

PTM Site: 322K

Affected site:

Position: 322

Residue: K

Type: ubiquitination

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
321T	LLEESS[P/T]PKLPRQSPG	1	proximal
321L	LLEESS[P/L]PKLPRQSPG	1	proximal
322E	LLEESSP[K/E]KLPRQSPG	0	direct
328L	LLEESSPKLPRQS[P/L]PG	6	distal
326L	LLEESSPKLPR[Q/L]QSPG	4	distal

PTM Site: 327S

Affected site:

Position: 327

Residue: S

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
321T	S[P/T]PKLPRQSPGSQSKD	6	distal
321L	S[P/L]PKLPRQSPGSQSKD	6	distal
322E	SP[K/E]KLPRQSPGSQSKD	5	distal
328L	SPKLPRQS[P/L]PGSQSKD	1	network-rewiring
326L	SPKLPR[Q/L]QSPGSQSKD	1	proximal

PTM Site: 333K

Affected site:

Position: 333

Residue: K

Type: ubiquitination

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
328L	QS[P/L]PGSQSKDLLRQGS	5	distal
334H	QSPGSQSK[D/H]DLLRQGS	1	proximal

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