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Mutation:
G2E3 P328L
Summary
Isoform:
Position:
328
Ref:
P
Mutation:
L
PTM impact:
network-rewiring
PTM affected:
3
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
[0.1461]
Minor Allele Frequency: (1000 Genomes)
[0.0399361]
PTM Site: 322K
Affected site:
Position: 322
Residue: K
Type: ubiquitination
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 321T | LLEESS[P/T]PKLPRQSPG | 1 |
proximal
|
| 321L | LLEESS[P/L]PKLPRQSPG | 1 |
proximal
|
| 322E | LLEESSP[K/E]KLPRQSPG | 0 |
direct
|
| 328L | LLEESSPKLPRQS[P/L]PG | 6 |
distal
|
| 326L | LLEESSPKLPR[Q/L]QSPG | 4 |
distal
|
PTM Site: 327S
Affected site:
Position: 327
Residue: S
Type: phosphorylation
Best loss of PTM site:
MAPK1 (probability p=0.954)
Site: 327S (phosphorylation)
Position in motif: 1
There are 8 other predicted
losses:
- MAPK3 (p=0.952)
- MAPK14 (p=0.943)
- CDK5 (p=0.94)
- CDK2 (p=0.928)
- CDK1 (p=0.921)
- GSK3B (p=0.894)
- MAPK8 (p=0.894)
- MAPK9 (p=0.873)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 321T | S[P/T]PKLPRQSPGSQSKD | 6 |
distal
|
| 321L | S[P/L]PKLPRQSPGSQSKD | 6 |
distal
|
| 322E | SP[K/E]KLPRQSPGSQSKD | 5 |
distal
|
| 328L | SPKLPRQS[P/L]PGSQSKD | 1 |
network-rewiring
|
| 326L | SPKLPR[Q/L]QSPGSQSKD | 1 |
proximal
|
PTM Site: 333K
Affected site:
Position: 333
Residue: K
Type: ubiquitination
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 328L | QS[P/L]PGSQSKDLLRQGS | 5 |
distal
|
| 334H | QSPGSQSK[D/H]DLLRQGS | 1 |
proximal
|
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