You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
UBE2O R512H
Summary
Isoform:
Position:
512
Ref:
R
Mutation:
H
PTM impact:
network-rewiring
PTM affected:
3
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
[0.0461]
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 514K
Affected site:
Position: 514
Residue: K
Type: ubiquitination
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 512H | GSGTS[R/H]RKKSIPLSIK | 2 |
proximal
|
| 510M | GSG[T/M]TSRKKSIPLSIK | 4 |
distal
|
| 517T | GSGTSRKKSI[P/T]PLSIK | 3 |
distal
|
PTM Site: 515S
Affected site:
Position: 515
Residue: S
Type: phosphorylation
Best loss of PTM site:
AKT1 (probability p=0.986)
Site: 515S (phosphorylation)
Position in motif: -3
There are 12 other predicted
losses:
- PRKACA (p=0.98)
- CHEK2 (p=0.96)
- PRKG1 (p=0.918)
- AKT2 (p=0.906)
- CAMK2A (p=0.9)
- CAMK1 (p=0.898)
- RPS6KA1 (p=0.88)
- PAK1 (p=0.878)
- RPS6KB1 (p=0.871)
- PRKD1 (p=0.869)
- PRKAA1 (p=0.866)
- DAPK3 (p=0.864)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 512H | SGTS[R/H]RKKSIPLSIKN | 3 |
network-rewiring
|
| 510M | SG[T/M]TSRKKSIPLSIKN | 5 |
distal
|
| 517T | SGTSRKKSI[P/T]PLSIKN | 2 |
proximal
|
PTM Site: 519S
Affected site:
Position: 519
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 517T | RKKSI[P/T]PLSIKNLKRK | 2 |
proximal
|
If you have any questions or feedback about this mutation:
Contact us