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Mutation:
NFATC1 P262Q
Summary
Isoform:
Position:
262
Ref:
P
Mutation:
Q
PTM impact:
distal
PTM affected:
3
Kinases:
PKA group,
PRKCA,
PRKACA,
PIM1,
DYRK1A,
PIM1
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
[0.0078]
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 256S
Affected site:
Position: 256
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 262Q | PCNKRKYSLNGRQ[P/Q]PP | 6 |
distal
|
| 260L | PCNKRKYSLNG[R/L]RQPP | 4 |
distal
|
PTM Site: 265S
Affected site:
Position: 265
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 262Q | NGRQ[P/Q]PPYSPHHSPTP | 3 |
distal
|
| 263A | NGRQP[P/A]PYSPHHSPTP | 2 |
proximal
|
| 268D | NGRQPPYSPH[H/D]HSPTP | 3 |
distal
|
| 267Y | NGRQPPYSP[H/Y]HHSPTP | 2 |
proximal
|
| 260L | NG[R/L]RQPPYSPHHSPTP | 5 |
distal
|
PTM Site: 269S
Affected site:
Position: 269
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 274L | PPYSPHHSPTPS[P/L]PHG | 5 |
distal
|
| 273P | PPYSPHHSPTP[S/P]SPHG | 4 |
distal
|
| 263A | P[P/A]PYSPHHSPTPSPHG | 6 |
distal
|
| 268D | PPYSPH[H/D]HSPTPSPHG | 1 |
proximal
|
| 267Y | PPYSP[H/Y]HHSPTPSPHG | 2 |
proximal
|
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