NFATC1 G276S

You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020

Mutation:

Summary

Isoform:

NM_172387

Position:

276

Ref:

Mutation:

PTM impact:

proximal

PTM affected:

Kinases:

PKA group, PRKACA, PRKCA

Clinical Information

Cancer types: (TCGA MC3)

THCA

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 269S

Affected site:

Position: 269

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
274L	PPYSPHHSPTPS[P/L]PHG	5	distal
273P	PPYSPHHSPTP[S/P]SPHG	4	distal
263A	P[P/A]PYSPHHSPTPSPHG	6	distal
268D	PPYSPH[H/D]HSPTPSPHG	1	proximal
267Y	PPYSP[H/Y]HHSPTPSPHG	2	proximal

PTM Site: 277S

Affected site:

Position: 277

Residue: S

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
274L	PTPS[P/L]PHGSPRVSVTD	3	distal
281T	PTPSPHGSPRV[S/T]SVTD	4	distal
282M	PTPSPHGSPRVS[V/M]VTD	5	distal
273P	PTP[S/P]SPHGSPRVSVTD	4	distal
276S	PTPSPH[G/S]GSPRVSVTD	1	proximal

PTM Site: 281S

Affected site:

Position: 281

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
281T	PHGSPRV[S/T]SVTDDSWL	0	direct
282M	PHGSPRVS[V/M]VTDDSWL	1	proximal
284N	PHGSPRVSVT[D/N]DDSWL	3	distal
286L	PHGSPRVSVTDD[S/L]SWL	5	distal
276S	PH[G/S]GSPRVSVTDDSWL	5	distal

If you have any questions or feedback about this mutation: