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Mutation:
NFATC1 S281T
Summary
Isoform:
Position:
281
Ref:
S
Mutation:
T
PTM impact:
direct
PTM affected:
2
Kinases:
PKA group,
PRKACA,
PRKCA
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
[0.0077]
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 277S
Affected site:
Position: 277
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 274L | PTPS[P/L]PHGSPRVSVTD | 3 |
distal
|
| 281T | PTPSPHGSPRV[S/T]SVTD | 4 |
distal
|
| 282M | PTPSPHGSPRVS[V/M]VTD | 5 |
distal
|
| 273P | PTP[S/P]SPHGSPRVSVTD | 4 |
distal
|
| 276S | PTPSPH[G/S]GSPRVSVTD | 1 |
proximal
|
PTM Site: 281S
Affected site:
Position: 281
Residue: S
Type: phosphorylation
Impact:
directOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 281T | PHGSPRV[S/T]SVTDDSWL | 0 |
direct
|
| 282M | PHGSPRVS[V/M]VTDDSWL | 1 |
proximal
|
| 284N | PHGSPRVSVT[D/N]DDSWL | 3 |
distal
|
| 286L | PHGSPRVSVTDD[S/L]SWL | 5 |
distal
|
| 276S | PH[G/S]GSPRVSVTDDSWL | 5 |
distal
|
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