1. Home
  2. Pathways
Login

After several years of serving the research community, our ActiveDriverDB database will be retired on May 1st 2026. Please make sure to download any data you need and update your links or workflows before that date.

We want to sincerely thank all our users for their support, feedback, and collaboration over the years — your contributions have been invaluable to this project. A special thank you to Dr. Michal Krassowski for leading the development of our open-source software and database.

For any questions or assistance, please contact Jüri Reimand (juri.reimand@utoronto.ca).

You are viewing an older version (2020) of the ActiveDriverDB. To view the current (2021) version please visit activedriverdb.org

Pathways

Significant pathways lists were computed using the ActivePathways method which takes the p-values of genes in a pathway into consideration; this is a more powerful and stringent approach compared to ranking pathways by the number of significant genes alone (see Pathways with significant genes column), which was used in the initial release of ActiveDriverDB (and is still provided for reference).

 

Mutations PTM type Significant pathways list Pathways* Pathways with significant genes Corresponding genes list Genes*
Clinical (ClinVar) all ActivePathways 906 Reactome pathways with significant genes Significant genes 595
Clinical (ClinVar) acetylation ActivePathways 21 Reactome pathways with significant genes Significant genes 35
Clinical (ClinVar) glycosylation ActivePathways 1 Reactome pathways with significant genes Significant genes 26
Clinical (ClinVar) methylation ActivePathways 6 Reactome pathways with significant genes Significant genes 40
Clinical (ClinVar) phosphorylation ActivePathways 746 Reactome pathways with significant genes Significant genes 338
Clinical (ClinVar) ubiquitination ActivePathways 304 Reactome pathways with significant genes Significant genes 232
Cancer (TCGA PanCancerAtlas) all ActivePathways 704 Reactome pathways with significant genes Significant genes 2681
Cancer (TCGA PanCancerAtlas) acetylation ActivePathways 98 Reactome pathways with significant genes Significant genes 52
Cancer (TCGA PanCancerAtlas) glycosylation ActivePathways 16 Reactome pathways with significant genes Significant genes 27
Cancer (TCGA PanCancerAtlas) methylation ActivePathways 61 Reactome pathways with significant genes Significant genes 170
Cancer (TCGA PanCancerAtlas) phosphorylation ActivePathways 507 Reactome pathways with significant genes Significant genes 1773
Cancer (TCGA PanCancerAtlas) ubiquitination ActivePathways 419 Reactome pathways with significant genes Significant genes 913

Alternatively, you can browse a list of all pathways.

*) number of significant pathways/genes on the list