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PTPN11 (NM_080601) - protein tyrosine phosphatase non-receptor type 11

Tyrosine-Protein Phosphatase Non-Receptor Type 11 Isoform 2

Mutations Visualisation

Protein summary

This is an alternative isoform of PTPN11 protein. View all 2 isoforms
PTPN11: tyrosine-protein phosphatase non-receptor type 11 isoform 2
Description:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016].

Strand
+
Chromosome
12
Protein
460 residues
All mutations
110
PTM sites
23
CDS
112,856,915 - 112,924,437
Transcription
112,856,535 - 112,924,727
0.65% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 5781
UniProt
Ensembl