Summary

Isoform:
Position:
282
Ref:
R
Mutation:
W
PTM impact:
network-rewiring
PTM affected:
1
Kinases:
AURKB

Clinical Information

Cancer types: (TCGA MC3)

COAD, PAAD, BRCA, PRAD, GBM, KICH, READ, UCEC, LUAD, ESCA, HNSC, STAD, LUSC, LGG, BLCA

Disease Annotations: (ClinVar)

Li-Fraumeni syndrome, Li-Fraumeni-like syndrome, Hereditary cancer-predisposing syndrome, Li-Fraumeni syndrome 1

Minor Allele Frequency: (ESP6500)

[0.0154]

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 284T

Affected site:

Position: 284
Residue: T
Type: phosphorylation

Best loss of PTM site:

AURKB (probability p=0.893)
Site: 284T (phosphorylation)
Position in motif: -2
There are 2 other predicted losses:
  • ROCK1 (p=0.874)
  • PRKACA (p=0.869)

Other known mutations affecting this site

Mutation In sequence Distance Impact
279R CP[G/R]GRDRRTEEENLRK 5
network-rewiring
285K CPGRDRRT[E/K]EEENLRK 1
proximal
280T CPG[R/T]RDRRTEEENLRK 4
distal
280K CPG[R/K]RDRRTEEENLRK 4
distal
278L C[P/L]PGRDRRTEEENLRK 6
distal
279E CP[G/E]GRDRRTEEENLRK 5
distal
282W CPGRD[R/W]RRTEEENLRK 2
network-rewiring
281V CPGR[D/V]DRRTEEENLRK 3
distal
278T C[P/T]PGRDRRTEEENLRK 6
distal
286A CPGRDRRTE[E/A]EENLRK 2
proximal
286K CPGRDRRTE[E/K]EENLRK 2
network-rewiring
278A C[P/A]PGRDRRTEEENLRK 6
distal
289F CPGRDRRTEEEN[L/F]LRK 5
distal
282G CPGRD[R/G]RRTEEENLRK 2
network-rewiring
286Q CPGRDRRTE[E/Q]EENLRK 2
proximal
278R C[P/R]PGRDRRTEEENLRK 6
distal
286G CPGRDRRTE[E/G]EENLRK 2
proximal
281A CPGR[D/A]DRRTEEENLRK 3
distal
281H CPGR[D/H]DRRTEEENLRK 3
distal
278S C[P/S]PGRDRRTEEENLRK 6
distal
283P CPGRDR[R/P]RTEEENLRK 1
proximal
280G CPG[R/G]RDRRTEEENLRK 4
distal
280S CPG[R/S]RDRRTEEENLRK 4
distal
286V CPGRDRRTE[E/V]EENLRK 2
proximal
281Y CPGR[D/Y]DRRTEEENLRK 3
distal
280I CPG[R/I]RDRRTEEENLRK 4
distal
281N CPGR[D/N]DRRTEEENLRK 3
distal
281E CPGR[D/E]DRRTEEENLRK 3
distal
278H C[P/H]PGRDRRTEEENLRK 6
distal
282Q CPGRD[R/Q]RRTEEENLRK 2
network-rewiring
284P CPGRDRR[T/P]TEEENLRK 0
direct
281G CPGR[D/G]DRRTEEENLRK 3
distal
290H CPGRDRRTEEENL[R/H]RK 6
distal
283H CPGRDR[R/H]RTEEENLRK 1
proximal
283C CPGRDR[R/C]RTEEENLRK 1
proximal
290C CPGRDRRTEEENL[R/C]RK 6
distal
287K CPGRDRRTEE[E/K]ENLRK 3
network-rewiring
285V CPGRDRRT[E/V]EEENLRK 1
proximal
284I CPGRDRR[T/I]TEEENLRK 0
direct
283S CPGRDR[R/S]RTEEENLRK 1
proximal
282L CPGRD[R/L]RRTEEENLRK 2
network-rewiring
287Q CPGRDRRTEE[E/Q]ENLRK 3
network-rewiring
285Q CPGRDRRT[E/Q]EEENLRK 1
network-rewiring
287D CPGRDRRTEE[E/D]ENLRK 3
distal

External references

dbSNP:

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