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Mutation:
TP53 L43F
Summary
Isoform:
Position:
43
Ref:
L
Mutation:
F
PTM impact:
distal
PTM affected:
2
Kinases:
PRKDC,
CHEK2,
DNA-PK,
CHEK1,
CSNK1A1,
MAPKAPK5,
ATM,
ATR,
CDK5,
PRKDC,
MAPK9,
DYRK2,
HIPK2,
MAPK14,
PRKCD,
ATM
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Li-Fraumeni syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 37S
Affected site:
Position: 37
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 43F | NVLSPLPSQAMDD[L/F]LM | 6 |
distal
|
| 43M | NVLSPLPSQAMDD[L/M]LM | 6 |
distal
|
| 42G | NVLSPLPSQAMD[D/G]DLM | 5 |
distal
|
| 41G | NVLSPLPSQAM[D/G]DDLM | 4 |
distal
|
| 41N | NVLSPLPSQAM[D/N]DDLM | 4 |
distal
|
| 39V | NVLSPLPSQ[A/V]AMDDLM | 2 |
proximal
|
| 38P | NVLSPLPS[Q/P]QAMDDLM | 1 |
network-rewiring
|
| 37F | NVLSPLP[S/F]SQAMDDLM | 0 |
direct
|
| 36L | NVLSPL[P/L]PSQAMDDLM | 1 |
proximal
|
| 36Q | NVLSPL[P/Q]PSQAMDDLM | 1 |
proximal
|
| 35M | NVLSP[L/M]LPSQAMDDLM | 2 |
proximal
|
| 34L | NVLS[P/L]PLPSQAMDDLM | 3 |
network-rewiring
|
| 34R | NVLS[P/R]PLPSQAMDDLM | 3 |
network-rewiring
|
| 34S | NVLS[P/S]PLPSQAMDDLM | 3 |
distal
|
| 34A | NVLS[P/A]PLPSQAMDDLM | 3 |
distal
|
| 34T | NVLS[P/T]PLPSQAMDDLM | 3 |
distal
|
| 33F | NVL[S/F]SPLPSQAMDDLM | 4 |
distal
|
| 33Y | NVL[S/Y]SPLPSQAMDDLM | 4 |
distal
|
| 31F | N[V/F]VLSPLPSQAMDDLM | 6 |
distal
|
| 31I | N[V/I]VLSPLPSQAMDDLM | 6 |
distal
|
PTM Site: 46S
Affected site:
Position: 46
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 52R | AMDDLMLSPDDIE[Q/R]QW | 6 |
distal
|
| 51G | AMDDLMLSPDDI[E/G]EQW | 5 |
distal
|
| 51K | AMDDLMLSPDDI[E/K]EQW | 5 |
distal
|
| 50T | AMDDLMLSPDD[I/T]IEQW | 4 |
distal
|
| 50N | AMDDLMLSPDD[I/N]IEQW | 4 |
distal
|
| 49G | AMDDLMLSPD[D/G]DIEQW | 3 |
network-rewiring
|
| 49H | AMDDLMLSPD[D/H]DIEQW | 3 |
network-rewiring
|
| 49N | AMDDLMLSPD[D/N]DIEQW | 3 |
network-rewiring
|
| 48E | AMDDLMLSP[D/E]DDIEQW | 2 |
proximal
|
| 47R | AMDDLMLS[P/R]PDDIEQW | 1 |
network-rewiring
|
| 47S | AMDDLMLS[P/S]PDDIEQW | 1 |
network-rewiring
|
| 47T | AMDDLMLS[P/T]PDDIEQW | 1 |
network-rewiring
|
| 46Y | AMDDLML[S/Y]SPDDIEQW | 0 |
direct
|
| 46P | AMDDLML[S/P]SPDDIEQW | 0 |
direct
|
| 45P | AMDDLM[L/P]LSPDDIEQW | 1 |
proximal
|
| 45V | AMDDLM[L/V]LSPDDIEQW | 1 |
proximal
|
| 44I | AMDDL[M/I]MLSPDDIEQW | 2 |
proximal
|
| 44R | AMDDL[M/R]MLSPDDIEQW | 2 |
network-rewiring
|
| 43F | AMDD[L/F]LMLSPDDIEQW | 3 |
distal
|
| 43M | AMDD[L/M]LMLSPDDIEQW | 3 |
distal
|
| 42G | AMD[D/G]DLMLSPDDIEQW | 4 |
distal
|
| 41G | AM[D/G]DDLMLSPDDIEQW | 5 |
distal
|
| 41N | AM[D/N]DDLMLSPDDIEQW | 5 |
distal
|
| 48N | AMDDLMLSP[D/N]DDIEQW | 2 |
proximal
|
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