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Mutation:
TP53 Q52R
Summary
Isoform:
Position:
52
Ref:
Q
Mutation:
R
PTM impact:
network-rewiring
PTM affected:
2
Kinases:
MAPK9,
DYRK2,
CDK5,
ATM,
PRKDC,
PRKCD,
HIPK2,
MAPK14, MAPK group,
MAPK1,
GRK5,
TAF1
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Li-Fraumeni syndrome, Hereditary cancer-predisposing syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 46S
Affected site:
Position: 46
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 52R | AMDDLMLSPDDIE[Q/R]QW | 6 |
distal
|
| 51G | AMDDLMLSPDDI[E/G]EQW | 5 |
distal
|
| 51K | AMDDLMLSPDDI[E/K]EQW | 5 |
distal
|
| 50T | AMDDLMLSPDD[I/T]IEQW | 4 |
distal
|
| 50N | AMDDLMLSPDD[I/N]IEQW | 4 |
distal
|
| 49G | AMDDLMLSPD[D/G]DIEQW | 3 |
network-rewiring
|
| 49H | AMDDLMLSPD[D/H]DIEQW | 3 |
network-rewiring
|
| 49N | AMDDLMLSPD[D/N]DIEQW | 3 |
network-rewiring
|
| 48E | AMDDLMLSP[D/E]DDIEQW | 2 |
proximal
|
| 47R | AMDDLMLS[P/R]PDDIEQW | 1 |
network-rewiring
|
| 47S | AMDDLMLS[P/S]PDDIEQW | 1 |
network-rewiring
|
| 47T | AMDDLMLS[P/T]PDDIEQW | 1 |
network-rewiring
|
| 46Y | AMDDLML[S/Y]SPDDIEQW | 0 |
direct
|
| 46P | AMDDLML[S/P]SPDDIEQW | 0 |
direct
|
| 45P | AMDDLM[L/P]LSPDDIEQW | 1 |
proximal
|
| 45V | AMDDLM[L/V]LSPDDIEQW | 1 |
proximal
|
| 44I | AMDDL[M/I]MLSPDDIEQW | 2 |
proximal
|
| 44R | AMDDL[M/R]MLSPDDIEQW | 2 |
network-rewiring
|
| 43F | AMDD[L/F]LMLSPDDIEQW | 3 |
distal
|
| 43M | AMDD[L/M]LMLSPDDIEQW | 3 |
distal
|
| 42G | AMD[D/G]DLMLSPDDIEQW | 4 |
distal
|
| 41G | AM[D/G]DDLMLSPDDIEQW | 5 |
distal
|
| 41N | AM[D/N]DDLMLSPDDIEQW | 5 |
distal
|
| 48N | AMDDLMLSP[D/N]DDIEQW | 2 |
proximal
|
PTM Site: 55T
Affected site:
Position: 55
Residue: T
Type: phosphorylation
Best gain of PTM site:
AKT1 (probability p=0.892)
Site: 55T (phosphorylation)
Position in motif: -3
There is 1 other predicted
gain:
- PRKAA1 (p=0.867)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 61E | DDIEQWFTEDPGP[D/E]DE | 6 |
distal
|
| 61G | DDIEQWFTEDPGP[D/G]DE | 6 |
distal
|
| 60L | DDIEQWFTEDPG[P/L]PDE | 5 |
distal
|
| 59D | DDIEQWFTEDP[G/D]GPDE | 4 |
distal
|
| 58R | DDIEQWFTED[P/R]PGPDE | 3 |
distal
|
| 58T | DDIEQWFTED[P/T]PGPDE | 3 |
distal
|
| 57E | DDIEQWFTE[D/E]DPGPDE | 2 |
proximal
|
| 54L | DDIEQW[F/L]FTEDPGPDE | 1 |
proximal
|
| 52R | DDIE[Q/R]QWFTEDPGPDE | 3 |
network-rewiring
|
| 51G | DDI[E/G]EQWFTEDPGPDE | 4 |
distal
|
| 51K | DDI[E/K]EQWFTEDPGPDE | 4 |
distal
|
| 50T | DD[I/T]IEQWFTEDPGPDE | 5 |
distal
|
| 50N | DD[I/N]IEQWFTEDPGPDE | 5 |
distal
|
| 49G | D[D/G]DIEQWFTEDPGPDE | 6 |
distal
|
| 49H | D[D/H]DIEQWFTEDPGPDE | 6 |
distal
|
| 49N | D[D/N]DIEQWFTEDPGPDE | 6 |
distal
|
| 57N | DDIEQWFTE[D/N]DPGPDE | 2 |
network-rewiring
|
External references
dbSNP:
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