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Mutation:
PKMYT1 R140C
Summary
Isoform:
Position:
140
Ref:
R
Mutation:
C
PTM impact:
network-rewiring
PTM affected:
3
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
[0.0798722]
PTM Site: 139K
Affected site:
Position: 139
Residue: K
Type: ubiquitination
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 142R | DGRLYAVKRS[M/R]MSPFR | 3 |
distal
|
| 140C | DGRLYAVK[R/C]RSMSPFR | 1 |
proximal
|
| 134Q | DG[R/Q]RLYAVKRSMSPFR | 5 |
distal
|
| 133S | D[G/S]GRLYAVKRSMSPFR | 6 |
distal
|
PTM Site: 141S
Affected site:
Position: 141
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 142R | RLYAVKRS[M/R]MSPFRGP | 1 |
proximal
|
| 146Q | RLYAVKRSMSPF[R/Q]RGP | 5 |
distal
|
| 140C | RLYAVK[R/C]RSMSPFRGP | 1 |
proximal
|
PTM Site: 143S
Affected site:
Position: 143
Residue: S
Type: phosphorylation, phosphorylation (SARS-CoV-2)
Best loss of PTM site:
AKT1 (probability p=0.976)
Site: 143S (phosphorylation (SARS-CoV-2), phosphorylation)
Position in motif: -3
There are 7 other predicted
losses:
- PRKACA (p=0.942)
- PRKCE (p=0.928)
- MAPKAPK2 (p=0.88)
- PRKG1 (p=0.875)
- PRKAA1 (p=0.875)
- PRKD1 (p=0.868)
- RPS6KA3 (p=0.867)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 142R | YAVKRS[M/R]MSPFRGPKD | 1 |
proximal
|
| 146Q | YAVKRSMSPF[R/Q]RGPKD | 3 |
distal
|
| 140C | YAVK[R/C]RSMSPFRGPKD | 3 |
network-rewiring
|
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