PKMYT1 R146Q

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Mutation:

Summary

Isoform:

NM_004203

Position:

146

Ref:

Mutation:

PTM impact:

distal

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

[0.0399361]

PTM Site: 139K

Affected site:

Position: 139

Residue: K

Type: ubiquitination

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
142R	DGRLYAVKRS[M/R]MSPFR	3	distal
140C	DGRLYAVK[R/C]RSMSPFR	1	proximal
134Q	DG[R/Q]RLYAVKRSMSPFR	5	distal
133S	D[G/S]GRLYAVKRSMSPFR	6	distal

PTM Site: 141S

Affected site:

Position: 141

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
142R	RLYAVKRS[M/R]MSPFRGP	1	proximal
146Q	RLYAVKRSMSPF[R/Q]RGP	5	distal
140C	RLYAVK[R/C]RSMSPFRGP	1	proximal

PTM Site: 143S

Affected site:

Position: 143

Residue: S

Type: phosphorylation, phosphorylation (SARS-CoV-2)

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
142R	YAVKRS[M/R]MSPFRGPKD	1	proximal
146Q	YAVKRSMSPF[R/Q]RGPKD	3	distal
140C	YAVK[R/C]RSMSPFRGPKD	3	network-rewiring

PTM Site: 149K

Affected site:

Position: 149

Residue: K

Type: ubiquitination

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
153P	MSPFRGPKDRA[R/P]RKLA	4	distal
153C	MSPFRGPKDRA[R/C]RKLA	4	distal
151Q	MSPFRGPKD[R/Q]RARKLA	2	proximal
146Q	MSPF[R/Q]RGPKDRARKLA	3	distal
152S	MSPFRGPKDR[A/S]ARKLA	3	distal
151W	MSPFRGPKD[R/W]RARKLA	2	proximal
154Q	MSPFRGPKDRAR[K/Q]KLA	5	distal

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