GMIP D436N

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Mutation:

Summary

Isoform:

NM_016573

Position:

436

Ref:

Mutation:

PTM impact:

network-rewiring

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

[0.0199681]

PTM Site: 430S

Affected site:

Position: 430

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
433W	VDSVGGGSES[R/W]RSLDS	3	distal
432C	VDSVGGGSE[S/C]SRSLDS	2	proximal
431Q	VDSVGGGS[E/Q]ESRSLDS	1	proximal
426M	VDS[V/M]VGGGSESRSLDS	4	distal
436N	VDSVGGGSESRSL[D/N]DS	6	distal
429C	VDSVGG[G/C]GSESRSLDS	1	proximal

PTM Site: 434S

Affected site:

Position: 434

Residue: S

Type: phosphorylation

Only loss of PTM site:

CAMK2A (probability p=0.935)

Site: 434S (phosphorylation)

Position in motif: 2

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
433W	GGGSES[R/W]RSLDSPTSS	1	proximal
432C	GGGSE[S/C]SRSLDSPTSS	2	proximal
431Q	GGGS[E/Q]ESRSLDSPTSS	3	distal
436N	GGGSESRSL[D/N]DSPTSS	2	network-rewiring
429C	GG[G/C]GSESRSLDSPTSS	5	distal
437A	GGGSESRSLD[S/A]SPTSS	3	network-rewiring
440F	GGGSESRSLDSPT[S/F]SS	6	distal

PTM Site: 437S

Affected site:

Position: 437

Residue: S

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
433W	SES[R/W]RSLDSPTSSPGA	4	distal
432C	SE[S/C]SRSLDSPTSSPGA	5	distal
431Q	S[E/Q]ESRSLDSPTSSPGA	6	distal
436N	SESRSL[D/N]DSPTSSPGA	1	proximal
437A	SESRSLD[S/A]SPTSSPGA	0	direct
440F	SESRSLDSPT[S/F]SSPGA	3	network-rewiring

PTM Site: 439T

Affected site:

Position: 439

Residue: T

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
433W	S[R/W]RSLDSPTSSPGAGT	6	distal
436N	SRSL[D/N]DSPTSSPGAGT	3	distal
437A	SRSLD[S/A]SPTSSPGAGT	2	proximal
440F	SRSLDSPT[S/F]SSPGAGT	1	proximal

PTM Site: 440S

Affected site:

Position: 440

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
446M	RSLDSPTSSPGAG[T/M]TR	6	distal
436N	RSL[D/N]DSPTSSPGAGTR	4	distal
437A	RSLD[S/A]SPTSSPGAGTR	3	distal
440F	RSLDSPT[S/F]SSPGAGTR	0	direct

PTM Site: 441S

Affected site:

Position: 441

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
446M	SLDSPTSSPGAG[T/M]TRQ	5	distal
436N	SL[D/N]DSPTSSPGAGTRQ	5	distal
437A	SLD[S/A]SPTSSPGAGTRQ	4	distal
440F	SLDSPT[S/F]SSPGAGTRQ	1	proximal

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