MAP2K5 R125Q

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Mutation:

Summary

Isoform:

NM_145160

Position:

125

Ref:

Mutation:

PTM impact:

direct

PTM affected:

Kinases:

MAPK7

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

[0.0154]

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 121K

Affected site:

Position: 121

Residue: K

Type: ubiquitination

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
125Q	ERNIHGLKVNT[R/Q]RAGP	4	distal
115W	E[R/W]RNIHGLKVNTRAGP	6	distal
118R	ERNI[H/R]HGLKVNTRAGP	3	distal
126S	ERNIHGLKVNTR[A/S]AGP	5	distal
127V	ERNIHGLKVNTRA[G/V]GP	6	distal

PTM Site: 125R

Affected site:

Position: 125

Residue: R

Type: methylation

Impact:

direct

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
125Q	HGLKVNT[R/Q]RAGPSQHS	0	direct
128S	HGLKVNTRAG[P/S]PSQHS	3	distal
131Y	HGLKVNTRAGPSQ[H/Y]HS	6	distal
126S	HGLKVNTR[A/S]AGPSQHS	1	proximal
127V	HGLKVNTRA[G/V]GPSQHS	2	proximal

PTM Site: 129S

Affected site:

Position: 129

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
125Q	VNT[R/Q]RAGPSQHSSPAV	4	distal
134L	VNTRAGPSQHSS[P/L]PAV	5	distal
128S	VNTRAG[P/S]PSQHSSPAV	1	proximal
131Y	VNTRAGPSQ[H/Y]HSSPAV	2	proximal
126S	VNTR[A/S]AGPSQHSSPAV	3	network-rewiring
127V	VNTRA[G/V]GPSQHSSPAV	2	proximal

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