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Mutation:
MAP2K5 A126S
Summary
Isoform:
Position:
126
Ref:
A
Mutation:
S
PTM impact:
network-rewiring
PTM affected:
4
Kinases:
MAPK7
Clinical Information
Cancer types: (TCGA MC3)
LUAD
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 121K
Affected site:
Position: 121
Residue: K
Type: ubiquitination
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 125Q | ERNIHGLKVNT[R/Q]RAGP | 4 |
distal
|
| 115W | E[R/W]RNIHGLKVNTRAGP | 6 |
distal
|
| 118R | ERNI[H/R]HGLKVNTRAGP | 3 |
distal
|
| 126S | ERNIHGLKVNTR[A/S]AGP | 5 |
distal
|
| 127V | ERNIHGLKVNTRA[G/V]GP | 6 |
distal
|
PTM Site: 125R
Affected site:
Position: 125
Residue: R
Type: methylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 125Q | HGLKVNT[R/Q]RAGPSQHS | 0 |
direct
|
| 128S | HGLKVNTRAG[P/S]PSQHS | 3 |
distal
|
| 131Y | HGLKVNTRAGPSQ[H/Y]HS | 6 |
distal
|
| 126S | HGLKVNTR[A/S]AGPSQHS | 1 |
proximal
|
| 127V | HGLKVNTRA[G/V]GPSQHS | 2 |
proximal
|
PTM Site: 129S
Affected site:
Position: 129
Residue: S
Type: phosphorylation
Only gain of PTM site:
CSNK1A1 (probability p=0.865)
Site: 129S (phosphorylation)
Position in motif: -3
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 125Q | VNT[R/Q]RAGPSQHSSPAV | 4 |
distal
|
| 134L | VNTRAGPSQHSS[P/L]PAV | 5 |
distal
|
| 128S | VNTRAG[P/S]PSQHSSPAV | 1 |
proximal
|
| 131Y | VNTRAGPSQ[H/Y]HSSPAV | 2 |
proximal
|
| 126S | VNTR[A/S]AGPSQHSSPAV | 3 |
network-rewiring
|
| 127V | VNTRA[G/V]GPSQHSSPAV | 2 |
proximal
|
PTM Site: 133S
Affected site:
Position: 133
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 134L | AGPSQHSS[P/L]PAVSDSL | 1 |
network-rewiring
|
| 136I | AGPSQHSSPA[V/I]VSDSL | 3 |
distal
|
| 128S | AG[P/S]PSQHSSPAVSDSL | 5 |
distal
|
| 131Y | AGPSQ[H/Y]HSSPAVSDSL | 2 |
proximal
|
| 136A | AGPSQHSSPA[V/A]VSDSL | 3 |
distal
|
| 138G | AGPSQHSSPAVS[D/G]DSL | 5 |
distal
|
| 127V | A[G/V]GPSQHSSPAVSDSL | 6 |
distal
|
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