1. Home
  2. Mutations
  3. MAP2K5 P134L
Login
You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:

MAP2K5 P134L

Summary

Isoform:
NM_145160
Position:
134
Ref:
P
Mutation:
L
PTM impact:
network-rewiring
PTM affected:
3
Kinases:
MAPK7, MAPK7

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

[0.0077]

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 129S

Affected site:

Position: 129
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
125Q VNT[R/Q]RAGPSQHSSPAV 4
distal
134L VNTRAGPSQHSS[P/L]PAV 5
distal
128S VNTRAG[P/S]PSQHSSPAV 1
proximal
131Y VNTRAGPSQ[H/Y]HSSPAV 2
proximal
126S VNTR[A/S]AGPSQHSSPAV 3
network-rewiring
127V VNTRA[G/V]GPSQHSSPAV 2
proximal

PTM Site: 133S

Affected site:

Position: 133
Residue: S
Type: phosphorylation

Only gain of PTM site:

PRKDC (probability p=0.973)
Site: 133S (phosphorylation)
Position in motif: 1

Best loss of PTM site:

MAPK8 (probability p=0.964)
Site: 133S (phosphorylation)
Position in motif: 1
There are 10 other predicted losses:
  • MAPK3 (p=0.954)
  • MAPK1 (p=0.953)
  • MAPK12 (p=0.947)
  • MAPK9 (p=0.942)
  • MAPK14 (p=0.938)
  • CDK1 (p=0.915)
  • HIPK2 (p=0.909)
  • CDK2 (p=0.896)
  • MAPK11 (p=0.895)
  • CDK7 (p=0.857)

Other known mutations affecting this site

Mutation In sequence Distance Impact
134L AGPSQHSS[P/L]PAVSDSL 1
network-rewiring
136I AGPSQHSSPA[V/I]VSDSL 3
distal
128S AG[P/S]PSQHSSPAVSDSL 5
distal
131Y AGPSQ[H/Y]HSSPAVSDSL 2
proximal
136A AGPSQHSSPA[V/A]VSDSL 3
distal
138G AGPSQHSSPAVS[D/G]DSL 5
distal
127V A[G/V]GPSQHSSPAVSDSL 6
distal

PTM Site: 137S

Affected site:

Position: 137
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
134L QHSS[P/L]PAVSDSLPSNS 3
distal
136I QHSSPA[V/I]VSDSLPSNS 1
proximal
131Y Q[H/Y]HSSPAVSDSLPSNS 6
distal
136A QHSSPA[V/A]VSDSLPSNS 1
proximal
138G QHSSPAVS[D/G]DSLPSNS 1
proximal

If you have any questions or feedback about this mutation:

Contact us