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Mutation:
MAP2K5 V136I
Summary
Isoform:
Position:
136
Ref:
V
Mutation:
I
PTM impact:
proximal
PTM affected:
4
Kinases:
MAPK7,
MAPK7,
MAPK7
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
[0.0077]
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 129S
Affected site:
Position: 129
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 125Q | VNT[R/Q]RAGPSQHSSPAV | 4 |
distal
|
| 134L | VNTRAGPSQHSS[P/L]PAV | 5 |
distal
|
| 128S | VNTRAG[P/S]PSQHSSPAV | 1 |
proximal
|
| 131Y | VNTRAGPSQ[H/Y]HSSPAV | 2 |
proximal
|
| 126S | VNTR[A/S]AGPSQHSSPAV | 3 |
network-rewiring
|
| 127V | VNTRA[G/V]GPSQHSSPAV | 2 |
proximal
|
PTM Site: 133S
Affected site:
Position: 133
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 134L | AGPSQHSS[P/L]PAVSDSL | 1 |
network-rewiring
|
| 136I | AGPSQHSSPA[V/I]VSDSL | 3 |
distal
|
| 128S | AG[P/S]PSQHSSPAVSDSL | 5 |
distal
|
| 131Y | AGPSQ[H/Y]HSSPAVSDSL | 2 |
proximal
|
| 136A | AGPSQHSSPA[V/A]VSDSL | 3 |
distal
|
| 138G | AGPSQHSSPAVS[D/G]DSL | 5 |
distal
|
| 127V | A[G/V]GPSQHSSPAVSDSL | 6 |
distal
|
PTM Site: 137S
Affected site:
Position: 137
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 134L | QHSS[P/L]PAVSDSLPSNS | 3 |
distal
|
| 136I | QHSSPA[V/I]VSDSLPSNS | 1 |
proximal
|
| 131Y | Q[H/Y]HSSPAVSDSLPSNS | 6 |
distal
|
| 136A | QHSSPA[V/A]VSDSLPSNS | 1 |
proximal
|
| 138G | QHSSPAVS[D/G]DSLPSNS | 1 |
proximal
|
PTM Site: 142S
Affected site:
Position: 142
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 136I | A[V/I]VSDSLPSNSLKKSS | 6 |
distal
|
| 136A | A[V/A]VSDSLPSNSLKKSS | 6 |
distal
|
| 138G | AVS[D/G]DSLPSNSLKKSS | 4 |
distal
|
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