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Mutation:
TP53 K101N
Summary
Isoform:
Position:
101
Ref:
K
Mutation:
N
PTM impact:
direct
PTM affected:
3
Kinases:
AURKA
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Hereditary cancer-predisposing syndrome, Li-Fraumeni syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 99S
Affected site:
Position: 99
Residue: S
Type: phosphorylation
Best loss of PTM site:
PRKCA (probability p=0.926)
Site: 99S (phosphorylation)
Position in motif: 2
There are 2 other predicted
losses:
- PRKCB (p=0.895)
- PRKCG (p=0.857)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 105V | PLSSSVPSQKTYQ[G/V]GS | 6 |
distal
|
| 105D | PLSSSVPSQKTYQ[G/D]GS | 6 |
distal
|
| 105R | PLSSSVPSQKTYQ[G/R]GS | 6 |
distal
|
| 105S | PLSSSVPSQKTYQ[G/S]GS | 6 |
distal
|
| 104L | PLSSSVPSQKTY[Q/L]QGS | 5 |
distal
|
| 103H | PLSSSVPSQKT[Y/H]YQGS | 4 |
distal
|
| 102I | PLSSSVPSQK[T/I]TYQGS | 3 |
distal
|
| 102S | PLSSSVPSQK[T/S]TYQGS | 3 |
distal
|
| 101N | PLSSSVPSQ[K/N]KTYQGS | 2 |
network-rewiring
|
| 101Q | PLSSSVPSQ[K/Q]KTYQGS | 2 |
network-rewiring
|
| 99F | PLSSSVP[S/F]SQKTYQGS | 0 |
direct
|
| 99C | PLSSSVP[S/C]SQKTYQGS | 0 |
direct
|
| 98L | PLSSSV[P/L]PSQKTYQGS | 1 |
proximal
|
| 98S | PLSSSV[P/S]PSQKTYQGS | 1 |
proximal
|
| 97F | PLSSS[V/F]VPSQKTYQGS | 2 |
proximal
|
| 105C | PLSSSVPSQKTYQ[G/C]GS | 6 |
distal
|
PTM Site: 101K
Affected site:
Position: 101
Residue: K
Type: ubiquitination
Impact:
directOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 107C | SSSVPSQKTYQGS[Y/C]YG | 6 |
distal
|
| 107S | SSSVPSQKTYQGS[Y/S]YG | 6 |
distal
|
| 107D | SSSVPSQKTYQGS[Y/D]YG | 6 |
distal
|
| 107H | SSSVPSQKTYQGS[Y/H]YG | 6 |
distal
|
| 107N | SSSVPSQKTYQGS[Y/N]YG | 6 |
distal
|
| 106R | SSSVPSQKTYQG[S/R]SYG | 5 |
distal
|
| 106I | SSSVPSQKTYQG[S/I]SYG | 5 |
distal
|
| 105V | SSSVPSQKTYQ[G/V]GSYG | 4 |
distal
|
| 105D | SSSVPSQKTYQ[G/D]GSYG | 4 |
distal
|
| 105R | SSSVPSQKTYQ[G/R]GSYG | 4 |
distal
|
| 105S | SSSVPSQKTYQ[G/S]GSYG | 4 |
distal
|
| 104L | SSSVPSQKTY[Q/L]QGSYG | 3 |
distal
|
| 103H | SSSVPSQKT[Y/H]YQGSYG | 2 |
proximal
|
| 102I | SSSVPSQK[T/I]TYQGSYG | 1 |
proximal
|
| 102S | SSSVPSQK[T/S]TYQGSYG | 1 |
proximal
|
| 101N | SSSVPSQ[K/N]KTYQGSYG | 0 |
direct
|
| 101Q | SSSVPSQ[K/Q]KTYQGSYG | 0 |
direct
|
| 99F | SSSVP[S/F]SQKTYQGSYG | 2 |
proximal
|
| 99C | SSSVP[S/C]SQKTYQGSYG | 2 |
proximal
|
| 98L | SSSV[P/L]PSQKTYQGSYG | 3 |
distal
|
| 98S | SSSV[P/S]PSQKTYQGSYG | 3 |
distal
|
| 97F | SSS[V/F]VPSQKTYQGSYG | 4 |
distal
|
| 105C | SSSVPSQKTYQ[G/C]GSYG | 4 |
distal
|
PTM Site: 106S
Affected site:
Position: 106
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
External references
dbSNP:
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