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You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:

TP53 F109C

Summary

Isoform:
NM_000546
Position:
109
Ref:
F
Mutation:
C
PTM impact:
proximal
PTM affected:
3
Kinases:
AURKA

Clinical Information

Cancer types: (TCGA MC3)

LUAD, READ, LUSC

Cancer types: (PCAWG)

ColoRect-AdenoCA

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 106S

Affected site:

Position: 106
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
112S SQKTYQGSYGFRL[G/S]GF 6
distal
111R SQKTYQGSYGFR[L/R]LGF 5
distal
111P SQKTYQGSYGFR[L/P]LGF 5
distal
111Q SQKTYQGSYGFR[L/Q]LGF 5
distal
111M SQKTYQGSYGFR[L/M]LGF 5
distal
110L SQKTYQGSYGF[R/L]RLGF 4
distal
110P SQKTYQGSYGF[R/P]RLGF 4
distal
110H SQKTYQGSYGF[R/H]RLGF 4
distal
110C SQKTYQGSYGF[R/C]RLGF 4
distal
110G SQKTYQGSYGF[R/G]RLGF 4
distal
110S SQKTYQGSYGF[R/S]RLGF 4
distal
109C SQKTYQGSYG[F/C]FRLGF 3
distal
108R SQKTYQGSY[G/R]GFRLGF 2
network-rewiring
108S SQKTYQGSY[G/S]GFRLGF 2
proximal
107C SQKTYQGS[Y/C]YGFRLGF 1
proximal
107S SQKTYQGS[Y/S]YGFRLGF 1
proximal
107D SQKTYQGS[Y/D]YGFRLGF 1
proximal
107H SQKTYQGS[Y/H]YGFRLGF 1
proximal
107N SQKTYQGS[Y/N]YGFRLGF 1
proximal
106R SQKTYQG[S/R]SYGFRLGF 0
direct
106I SQKTYQG[S/I]SYGFRLGF 0
direct
105V SQKTYQ[G/V]GSYGFRLGF 1
proximal
105D SQKTYQ[G/D]GSYGFRLGF 1
proximal
105R SQKTYQ[G/R]GSYGFRLGF 1
proximal
105S SQKTYQ[G/S]GSYGFRLGF 1
proximal
104L SQKTY[Q/L]QGSYGFRLGF 2
proximal
103H SQKT[Y/H]YQGSYGFRLGF 3
distal
102I SQK[T/I]TYQGSYGFRLGF 4
distal
102S SQK[T/S]TYQGSYGFRLGF 4
distal
101N SQ[K/N]KTYQGSYGFRLGF 5
distal
101Q SQ[K/Q]KTYQGSYGFRLGF 5
distal
105C SQKTYQ[G/C]GSYGFRLGF 1
proximal
109V SQKTYQGSYG[F/V]FRLGF 3
distal
109S SQKTYQGSYG[F/S]FRLGF 3
distal

PTM Site: 110R

Affected site:

Position: 110
Residue: R
Type: methylation

Impact:

proximal

Other known mutations affecting this site

Mutation In sequence Distance Impact
116A YQGSYGFRLGFLH[S/A]SG 6
distal
115R YQGSYGFRLGFL[H/R]HSG 5
distal
115N YQGSYGFRLGFL[H/N]HSG 5
distal
114S YQGSYGFRLGF[L/S]LHSG 4
distal
113C YQGSYGFRLG[F/C]FLHSG 3
distal
113S YQGSYGFRLG[F/S]FLHSG 3
distal
113V YQGSYGFRLG[F/V]FLHSG 3
distal
112S YQGSYGFRL[G/S]GFLHSG 2
proximal
111R YQGSYGFR[L/R]LGFLHSG 1
proximal
111P YQGSYGFR[L/P]LGFLHSG 1
proximal
111Q YQGSYGFR[L/Q]LGFLHSG 1
proximal
111M YQGSYGFR[L/M]LGFLHSG 1
proximal
110L YQGSYGF[R/L]RLGFLHSG 0
direct
110P YQGSYGF[R/P]RLGFLHSG 0
direct
110H YQGSYGF[R/H]RLGFLHSG 0
direct
110C YQGSYGF[R/C]RLGFLHSG 0
direct
110G YQGSYGF[R/G]RLGFLHSG 0
direct
110S YQGSYGF[R/S]RLGFLHSG 0
direct
109C YQGSYG[F/C]FRLGFLHSG 1
proximal
108R YQGSY[G/R]GFRLGFLHSG 2
proximal
108S YQGSY[G/S]GFRLGFLHSG 2
proximal
107C YQGS[Y/C]YGFRLGFLHSG 3
distal
107S YQGS[Y/S]YGFRLGFLHSG 3
distal
107D YQGS[Y/D]YGFRLGFLHSG 3
distal
107H YQGS[Y/H]YGFRLGFLHSG 3
distal
107N YQGS[Y/N]YGFRLGFLHSG 3
distal
106R YQG[S/R]SYGFRLGFLHSG 4
distal
106I YQG[S/I]SYGFRLGFLHSG 4
distal
105V YQ[G/V]GSYGFRLGFLHSG 5
distal
105D YQ[G/D]GSYGFRLGFLHSG 5
distal
105R YQ[G/R]GSYGFRLGFLHSG 5
distal
105S YQ[G/S]GSYGFRLGFLHSG 5
distal
104L Y[Q/L]QGSYGFRLGFLHSG 6
distal
105C YQ[G/C]GSYGFRLGFLHSG 5
distal
109V YQGSYG[F/V]FRLGFLHSG 1
proximal
113L YQGSYGFRLG[F/L]FLHSG 3
distal
109S YQGSYG[F/S]FRLGFLHSG 1
proximal
113I YQGSYGFRLG[F/I]FLHSG 3
distal

PTM Site: 115H

Affected site:

Position: 115
Residue: H
Type: methylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
121P GFRLGFLHSGTAK[S/P]SV 6
distal
120E GFRLGFLHSGTA[K/E]KSV 5
distal
119G GFRLGFLHSGT[A/G]AKSV 4
distal
119P GFRLGFLHSGT[A/P]AKSV 4
distal
118I GFRLGFLHSG[T/I]TAKSV 3
distal
117V GFRLGFLHS[G/V]GTAKSV 2
proximal
117R GFRLGFLHS[G/R]GTAKSV 2
proximal
116A GFRLGFLH[S/A]SGTAKSV 1
proximal
115R GFRLGFL[H/R]HSGTAKSV 0
direct
115N GFRLGFL[H/N]HSGTAKSV 0
direct
114S GFRLGF[L/S]LHSGTAKSV 1
proximal
113C GFRLG[F/C]FLHSGTAKSV 2
proximal
113S GFRLG[F/S]FLHSGTAKSV 2
proximal
113V GFRLG[F/V]FLHSGTAKSV 2
proximal
112S GFRL[G/S]GFLHSGTAKSV 3
distal
111R GFR[L/R]LGFLHSGTAKSV 4
distal
111P GFR[L/P]LGFLHSGTAKSV 4
distal
111Q GFR[L/Q]LGFLHSGTAKSV 4
distal
111M GFR[L/M]LGFLHSGTAKSV 4
distal
110L GF[R/L]RLGFLHSGTAKSV 5
distal
110P GF[R/P]RLGFLHSGTAKSV 5
distal
110H GF[R/H]RLGFLHSGTAKSV 5
distal
110C GF[R/C]RLGFLHSGTAKSV 5
distal
110G GF[R/G]RLGFLHSGTAKSV 5
distal
110S GF[R/S]RLGFLHSGTAKSV 5
distal
109C G[F/C]FRLGFLHSGTAKSV 6
distal
109V G[F/V]FRLGFLHSGTAKSV 6
distal
113L GFRLG[F/L]FLHSGTAKSV 2
proximal
109S G[F/S]FRLGFLHSGTAKSV 6
distal
121Y GFRLGFLHSGTAK[S/Y]SV 6
distal
113I GFRLG[F/I]FLHSGTAKSV 2
proximal

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