TP53 S99C

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Mutation:

Summary

Isoform:

NM_000546

Position:

Ref:

Mutation:

PTM impact:

direct

PTM affected:

Kinases:

AURKA

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

Li-Fraumeni syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 99S

Affected site:

Position: 99

Residue: S

Type: phosphorylation

Impact:

direct

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
105V	PLSSSVPSQKTYQ[G/V]GS	6	distal
105D	PLSSSVPSQKTYQ[G/D]GS	6	distal
105R	PLSSSVPSQKTYQ[G/R]GS	6	distal
105S	PLSSSVPSQKTYQ[G/S]GS	6	distal
104L	PLSSSVPSQKTY[Q/L]QGS	5	distal
103H	PLSSSVPSQKT[Y/H]YQGS	4	distal
102I	PLSSSVPSQK[T/I]TYQGS	3	distal
102S	PLSSSVPSQK[T/S]TYQGS	3	distal
101N	PLSSSVPSQ[K/N]KTYQGS	2	network-rewiring
101Q	PLSSSVPSQ[K/Q]KTYQGS	2	network-rewiring
99F	PLSSSVP[S/F]SQKTYQGS	0	direct
99C	PLSSSVP[S/C]SQKTYQGS	0	direct
98L	PLSSSV[P/L]PSQKTYQGS	1	proximal
98S	PLSSSV[P/S]PSQKTYQGS	1	proximal
97F	PLSSS[V/F]VPSQKTYQGS	2	proximal
105C	PLSSSVPSQKTYQ[G/C]GS	6	distal

PTM Site: 101K

Affected site:

Position: 101

Residue: K

Type: ubiquitination

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
107C	SSSVPSQKTYQGS[Y/C]YG	6	distal
107S	SSSVPSQKTYQGS[Y/S]YG	6	distal
107D	SSSVPSQKTYQGS[Y/D]YG	6	distal
107H	SSSVPSQKTYQGS[Y/H]YG	6	distal
107N	SSSVPSQKTYQGS[Y/N]YG	6	distal
106R	SSSVPSQKTYQG[S/R]SYG	5	distal
106I	SSSVPSQKTYQG[S/I]SYG	5	distal
105V	SSSVPSQKTYQ[G/V]GSYG	4	distal
105D	SSSVPSQKTYQ[G/D]GSYG	4	distal
105R	SSSVPSQKTYQ[G/R]GSYG	4	distal
105S	SSSVPSQKTYQ[G/S]GSYG	4	distal
104L	SSSVPSQKTY[Q/L]QGSYG	3	distal
103H	SSSVPSQKT[Y/H]YQGSYG	2	proximal
102I	SSSVPSQK[T/I]TYQGSYG	1	proximal
102S	SSSVPSQK[T/S]TYQGSYG	1	proximal
101N	SSSVPSQ[K/N]KTYQGSYG	0	direct
101Q	SSSVPSQ[K/Q]KTYQGSYG	0	direct
99F	SSSVP[S/F]SQKTYQGSYG	2	proximal
99C	SSSVP[S/C]SQKTYQGSYG	2	proximal
98L	SSSV[P/L]PSQKTYQGSYG	3	distal
98S	SSSV[P/S]PSQKTYQGSYG	3	distal
97F	SSS[V/F]VPSQKTYQGSYG	4	distal
105C	SSSVPSQKTYQ[G/C]GSYG	4	distal

PTM Site: 106S

Affected site:

Position: 106

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
112S	SQKTYQGSYGFRL[G/S]GF	6	distal
111R	SQKTYQGSYGFR[L/R]LGF	5	distal
111P	SQKTYQGSYGFR[L/P]LGF	5	distal
111Q	SQKTYQGSYGFR[L/Q]LGF	5	distal
111M	SQKTYQGSYGFR[L/M]LGF	5	distal
110L	SQKTYQGSYGF[R/L]RLGF	4	distal
110P	SQKTYQGSYGF[R/P]RLGF	4	distal
110H	SQKTYQGSYGF[R/H]RLGF	4	distal
110C	SQKTYQGSYGF[R/C]RLGF	4	distal
110G	SQKTYQGSYGF[R/G]RLGF	4	distal
110S	SQKTYQGSYGF[R/S]RLGF	4	distal
109C	SQKTYQGSYG[F/C]FRLGF	3	distal
108R	SQKTYQGSY[G/R]GFRLGF	2	network-rewiring
108S	SQKTYQGSY[G/S]GFRLGF	2	proximal
107C	SQKTYQGS[Y/C]YGFRLGF	1	proximal
107S	SQKTYQGS[Y/S]YGFRLGF	1	proximal
107D	SQKTYQGS[Y/D]YGFRLGF	1	proximal
107H	SQKTYQGS[Y/H]YGFRLGF	1	proximal
107N	SQKTYQGS[Y/N]YGFRLGF	1	proximal
106R	SQKTYQG[S/R]SYGFRLGF	0	direct
106I	SQKTYQG[S/I]SYGFRLGF	0	direct
105V	SQKTYQ[G/V]GSYGFRLGF	1	proximal
105D	SQKTYQ[G/D]GSYGFRLGF	1	proximal
105R	SQKTYQ[G/R]GSYGFRLGF	1	proximal
105S	SQKTYQ[G/S]GSYGFRLGF	1	proximal
104L	SQKTY[Q/L]QGSYGFRLGF	2	proximal
103H	SQKT[Y/H]YQGSYGFRLGF	3	distal
102I	SQK[T/I]TYQGSYGFRLGF	4	distal
102S	SQK[T/S]TYQGSYGFRLGF	4	distal
101N	SQ[K/N]KTYQGSYGFRLGF	5	distal
101Q	SQ[K/Q]KTYQGSYGFRLGF	5	distal
105C	SQKTYQ[G/C]GSYGFRLGF	1	proximal
109V	SQKTYQGSYG[F/V]FRLGF	3	distal
109S	SQKTYQGSYG[F/S]FRLGF	3	distal

External references

dbSNP:

rs1567556019

If you have any questions or feedback about this mutation: