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Mutation:

TP53 S106R

Summary

Isoform:
NM_000546
Position:
106
Ref:
S
Mutation:
R
PTM impact:
direct
PTM affected:
4
Kinases:
AURKA

Clinical Information

Cancer types: (TCGA MC3)

LUSC, HNSC, LIHC, ESCA

Cancer types: (PCAWG)

Panc-AdenoCA

Disease Annotations: (ClinVar)

Li-Fraumeni syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 99S

Affected site:

Position: 99
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
105V PLSSSVPSQKTYQ[G/V]GS 6
distal
105D PLSSSVPSQKTYQ[G/D]GS 6
distal
105R PLSSSVPSQKTYQ[G/R]GS 6
distal
105S PLSSSVPSQKTYQ[G/S]GS 6
distal
104L PLSSSVPSQKTY[Q/L]QGS 5
distal
103H PLSSSVPSQKT[Y/H]YQGS 4
distal
102I PLSSSVPSQK[T/I]TYQGS 3
distal
102S PLSSSVPSQK[T/S]TYQGS 3
distal
101N PLSSSVPSQ[K/N]KTYQGS 2
network-rewiring
101Q PLSSSVPSQ[K/Q]KTYQGS 2
network-rewiring
99F PLSSSVP[S/F]SQKTYQGS 0
direct
99C PLSSSVP[S/C]SQKTYQGS 0
direct
98L PLSSSV[P/L]PSQKTYQGS 1
proximal
98S PLSSSV[P/S]PSQKTYQGS 1
proximal
97F PLSSS[V/F]VPSQKTYQGS 2
proximal
105C PLSSSVPSQKTYQ[G/C]GS 6
distal

PTM Site: 101K

Affected site:

Position: 101
Residue: K
Type: ubiquitination

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
107C SSSVPSQKTYQGS[Y/C]YG 6
distal
107S SSSVPSQKTYQGS[Y/S]YG 6
distal
107D SSSVPSQKTYQGS[Y/D]YG 6
distal
107H SSSVPSQKTYQGS[Y/H]YG 6
distal
107N SSSVPSQKTYQGS[Y/N]YG 6
distal
106R SSSVPSQKTYQG[S/R]SYG 5
distal
106I SSSVPSQKTYQG[S/I]SYG 5
distal
105V SSSVPSQKTYQ[G/V]GSYG 4
distal
105D SSSVPSQKTYQ[G/D]GSYG 4
distal
105R SSSVPSQKTYQ[G/R]GSYG 4
distal
105S SSSVPSQKTYQ[G/S]GSYG 4
distal
104L SSSVPSQKTY[Q/L]QGSYG 3
distal
103H SSSVPSQKT[Y/H]YQGSYG 2
proximal
102I SSSVPSQK[T/I]TYQGSYG 1
proximal
102S SSSVPSQK[T/S]TYQGSYG 1
proximal
101N SSSVPSQ[K/N]KTYQGSYG 0
direct
101Q SSSVPSQ[K/Q]KTYQGSYG 0
direct
99F SSSVP[S/F]SQKTYQGSYG 2
proximal
99C SSSVP[S/C]SQKTYQGSYG 2
proximal
98L SSSV[P/L]PSQKTYQGSYG 3
distal
98S SSSV[P/S]PSQKTYQGSYG 3
distal
97F SSS[V/F]VPSQKTYQGSYG 4
distal
105C SSSVPSQKTYQ[G/C]GSYG 4
distal

PTM Site: 106S

Affected site:

Position: 106
Residue: S
Type: phosphorylation

Impact:

direct

Other known mutations affecting this site

Mutation In sequence Distance Impact
112S SQKTYQGSYGFRL[G/S]GF 6
distal
111R SQKTYQGSYGFR[L/R]LGF 5
distal
111P SQKTYQGSYGFR[L/P]LGF 5
distal
111Q SQKTYQGSYGFR[L/Q]LGF 5
distal
111M SQKTYQGSYGFR[L/M]LGF 5
distal
110L SQKTYQGSYGF[R/L]RLGF 4
distal
110P SQKTYQGSYGF[R/P]RLGF 4
distal
110H SQKTYQGSYGF[R/H]RLGF 4
distal
110C SQKTYQGSYGF[R/C]RLGF 4
distal
110G SQKTYQGSYGF[R/G]RLGF 4
distal
110S SQKTYQGSYGF[R/S]RLGF 4
distal
109C SQKTYQGSYG[F/C]FRLGF 3
distal
108R SQKTYQGSY[G/R]GFRLGF 2
network-rewiring
108S SQKTYQGSY[G/S]GFRLGF 2
proximal
107C SQKTYQGS[Y/C]YGFRLGF 1
proximal
107S SQKTYQGS[Y/S]YGFRLGF 1
proximal
107D SQKTYQGS[Y/D]YGFRLGF 1
proximal
107H SQKTYQGS[Y/H]YGFRLGF 1
proximal
107N SQKTYQGS[Y/N]YGFRLGF 1
proximal
106R SQKTYQG[S/R]SYGFRLGF 0
direct
106I SQKTYQG[S/I]SYGFRLGF 0
direct
105V SQKTYQ[G/V]GSYGFRLGF 1
proximal
105D SQKTYQ[G/D]GSYGFRLGF 1
proximal
105R SQKTYQ[G/R]GSYGFRLGF 1
proximal
105S SQKTYQ[G/S]GSYGFRLGF 1
proximal
104L SQKTY[Q/L]QGSYGFRLGF 2
proximal
103H SQKT[Y/H]YQGSYGFRLGF 3
distal
102I SQK[T/I]TYQGSYGFRLGF 4
distal
102S SQK[T/S]TYQGSYGFRLGF 4
distal
101N SQ[K/N]KTYQGSYGFRLGF 5
distal
101Q SQ[K/Q]KTYQGSYGFRLGF 5
distal
105C SQKTYQ[G/C]GSYGFRLGF 1
proximal
109V SQKTYQGSYG[F/V]FRLGF 3
distal
109S SQKTYQGSYG[F/S]FRLGF 3
distal

PTM Site: 110R

Affected site:

Position: 110
Residue: R
Type: methylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
116A YQGSYGFRLGFLH[S/A]SG 6
distal
115R YQGSYGFRLGFL[H/R]HSG 5
distal
115N YQGSYGFRLGFL[H/N]HSG 5
distal
114S YQGSYGFRLGF[L/S]LHSG 4
distal
113C YQGSYGFRLG[F/C]FLHSG 3
distal
113S YQGSYGFRLG[F/S]FLHSG 3
distal
113V YQGSYGFRLG[F/V]FLHSG 3
distal
112S YQGSYGFRL[G/S]GFLHSG 2
proximal
111R YQGSYGFR[L/R]LGFLHSG 1
proximal
111P YQGSYGFR[L/P]LGFLHSG 1
proximal
111Q YQGSYGFR[L/Q]LGFLHSG 1
proximal
111M YQGSYGFR[L/M]LGFLHSG 1
proximal
110L YQGSYGF[R/L]RLGFLHSG 0
direct
110P YQGSYGF[R/P]RLGFLHSG 0
direct
110H YQGSYGF[R/H]RLGFLHSG 0
direct
110C YQGSYGF[R/C]RLGFLHSG 0
direct
110G YQGSYGF[R/G]RLGFLHSG 0
direct
110S YQGSYGF[R/S]RLGFLHSG 0
direct
109C YQGSYG[F/C]FRLGFLHSG 1
proximal
108R YQGSY[G/R]GFRLGFLHSG 2
proximal
108S YQGSY[G/S]GFRLGFLHSG 2
proximal
107C YQGS[Y/C]YGFRLGFLHSG 3
distal
107S YQGS[Y/S]YGFRLGFLHSG 3
distal
107D YQGS[Y/D]YGFRLGFLHSG 3
distal
107H YQGS[Y/H]YGFRLGFLHSG 3
distal
107N YQGS[Y/N]YGFRLGFLHSG 3
distal
106R YQG[S/R]SYGFRLGFLHSG 4
distal
106I YQG[S/I]SYGFRLGFLHSG 4
distal
105V YQ[G/V]GSYGFRLGFLHSG 5
distal
105D YQ[G/D]GSYGFRLGFLHSG 5
distal
105R YQ[G/R]GSYGFRLGFLHSG 5
distal
105S YQ[G/S]GSYGFRLGFLHSG 5
distal
104L Y[Q/L]QGSYGFRLGFLHSG 6
distal
105C YQ[G/C]GSYGFRLGFLHSG 5
distal
109V YQGSYG[F/V]FRLGFLHSG 1
proximal
113L YQGSYGFRLG[F/L]FLHSG 3
distal
109S YQGSYG[F/S]FRLGFLHSG 1
proximal
113I YQGSYGFRLG[F/I]FLHSG 3
distal

External references

dbSNP:
rs1555526581

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