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You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:

TP53 I332F

Summary

Isoform:
NM_000546
Position:
332
Ref:
I
Mutation:
F
PTM impact:
proximal
PTM affected:
4
Kinases:

Clinical Information

Cancer types: (TCGA MC3)

LIHC

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 327Y

Affected site:

Position: 327
Residue: Y
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
333H KKPLDGEYFTLQI[R/H]RG 6
distal
333C KKPLDGEYFTLQI[R/C]RG 6
distal
332M KKPLDGEYFTLQ[I/M]IRG 5
distal
331R KKPLDGEYFTL[Q/R]QIRG 4
distal
331K KKPLDGEYFTL[Q/K]QIRG 4
distal
330P KKPLDGEYFT[L/P]LQIRG 3
distal
329I KKPLDGEYF[T/I]TLQIRG 2
proximal
329A KKPLDGEYF[T/A]TLQIRG 2
proximal
328S KKPLDGEY[F/S]FTLQIRG 1
proximal
325V KKPLD[G/V]GEYFTLQIRG 2
proximal
325E KKPLD[G/E]GEYFTLQIRG 2
proximal
325R KKPLD[G/R]GEYFTLQIRG 2
proximal
324Y KKPL[D/Y]DGEYFTLQIRG 3
network-rewiring
324H KKPL[D/H]DGEYFTLQIRG 3
network-rewiring
323P KKP[L/P]LDGEYFTLQIRG 4
distal
322S KK[P/S]PLDGEYFTLQIRG 5
distal
322T KK[P/T]PLDGEYFTLQIRG 5
distal
331H KKPLDGEYFTL[Q/H]QIRG 4
distal
332F KKPLDGEYFTLQ[I/F]IRG 5
distal

PTM Site: 333R

Affected site:

Position: 333
Residue: R
Type: methylation

Impact:

proximal

Other known mutations affecting this site

Mutation In sequence Distance Impact
339V EYFTLQIRGRERF[E/V]EM 6
distal
339G EYFTLQIRGRERF[E/G]EM 6
distal
339Q EYFTLQIRGRERF[E/Q]EM 6
distal
339K EYFTLQIRGRERF[E/K]EM 6
distal
338L EYFTLQIRGRER[F/L]FEM 5
distal
338C EYFTLQIRGRER[F/C]FEM 5
distal
337L EYFTLQIRGRE[R/L]RFEM 4
distal
337P EYFTLQIRGRE[R/P]RFEM 4
distal
337H EYFTLQIRGRE[R/H]RFEM 4
distal
337C EYFTLQIRGRE[R/C]RFEM 4
distal
337G EYFTLQIRGRE[R/G]RFEM 4
distal
335P EYFTLQIRG[R/P]RERFEM 2
proximal
335H EYFTLQIRG[R/H]RERFEM 2
proximal
335C EYFTLQIRG[R/C]RERFEM 2
proximal
334E EYFTLQIR[G/E]GRERFEM 1
proximal
334W EYFTLQIR[G/W]GRERFEM 1
proximal
334R EYFTLQIR[G/R]GRERFEM 1
proximal
333H EYFTLQI[R/H]RGRERFEM 0
direct
333C EYFTLQI[R/C]RGRERFEM 0
direct
332M EYFTLQ[I/M]IRGRERFEM 1
proximal
331R EYFTL[Q/R]QIRGRERFEM 2
proximal
331K EYFTL[Q/K]QIRGRERFEM 2
proximal
330P EYFT[L/P]LQIRGRERFEM 3
distal
329I EYF[T/I]TLQIRGRERFEM 4
distal
329A EYF[T/A]TLQIRGRERFEM 4
distal
328S EY[F/S]FTLQIRGRERFEM 5
distal
334V EYFTLQIR[G/V]GRERFEM 1
proximal
331H EYFTL[Q/H]QIRGRERFEM 2
proximal
337S EYFTLQIRGRE[R/S]RFEM 4
distal
338I EYFTLQIRGRER[F/I]FEM 5
distal
332F EYFTLQ[I/F]IRGRERFEM 1
proximal

PTM Site: 335R

Affected site:

Position: 335
Residue: R
Type: methylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
340K FTLQIRGRERFE[M/K]MFR 5
distal
339V FTLQIRGRERF[E/V]EMFR 4
distal
339G FTLQIRGRERF[E/G]EMFR 4
distal
339Q FTLQIRGRERF[E/Q]EMFR 4
distal
339K FTLQIRGRERF[E/K]EMFR 4
distal
338L FTLQIRGRER[F/L]FEMFR 3
distal
338C FTLQIRGRER[F/C]FEMFR 3
distal
337L FTLQIRGRE[R/L]RFEMFR 2
proximal
337P FTLQIRGRE[R/P]RFEMFR 2
proximal
337H FTLQIRGRE[R/H]RFEMFR 2
proximal
337C FTLQIRGRE[R/C]RFEMFR 2
proximal
337G FTLQIRGRE[R/G]RFEMFR 2
proximal
335P FTLQIRG[R/P]RERFEMFR 0
direct
335H FTLQIRG[R/H]RERFEMFR 0
direct
335C FTLQIRG[R/C]RERFEMFR 0
direct
334E FTLQIR[G/E]GRERFEMFR 1
proximal
334W FTLQIR[G/W]GRERFEMFR 1
proximal
334R FTLQIR[G/R]GRERFEMFR 1
proximal
333H FTLQI[R/H]RGRERFEMFR 2
proximal
333C FTLQI[R/C]RGRERFEMFR 2
proximal
332M FTLQ[I/M]IRGRERFEMFR 3
distal
331R FTL[Q/R]QIRGRERFEMFR 4
distal
331K FTL[Q/K]QIRGRERFEMFR 4
distal
330P FT[L/P]LQIRGRERFEMFR 5
distal
329I F[T/I]TLQIRGRERFEMFR 6
distal
329A F[T/A]TLQIRGRERFEMFR 6
distal
334V FTLQIR[G/V]GRERFEMFR 1
proximal
331H FTL[Q/H]QIRGRERFEMFR 4
distal
341L FTLQIRGRERFEM[F/L]FR 6
distal
341V FTLQIRGRERFEM[F/V]FR 6
distal
337S FTLQIRGRE[R/S]RFEMFR 2
proximal
338I FTLQIRGRER[F/I]FEMFR 3
distal
332F FTLQ[I/F]IRGRERFEMFR 3
distal

PTM Site: 337R

Affected site:

Position: 337
Residue: R
Type: methylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
342P LQIRGRERFEMF[R/P]REL 5
distal
342Q LQIRGRERFEMF[R/Q]REL 5
distal
340K LQIRGRERFE[M/K]MFREL 3
distal
339V LQIRGRERF[E/V]EMFREL 2
proximal
339G LQIRGRERF[E/G]EMFREL 2
proximal
339Q LQIRGRERF[E/Q]EMFREL 2
proximal
339K LQIRGRERF[E/K]EMFREL 2
proximal
338L LQIRGRER[F/L]FEMFREL 1
proximal
338C LQIRGRER[F/C]FEMFREL 1
proximal
337L LQIRGRE[R/L]RFEMFREL 0
direct
337P LQIRGRE[R/P]RFEMFREL 0
direct
337H LQIRGRE[R/H]RFEMFREL 0
direct
337C LQIRGRE[R/C]RFEMFREL 0
direct
337G LQIRGRE[R/G]RFEMFREL 0
direct
335P LQIRG[R/P]RERFEMFREL 2
proximal
335H LQIRG[R/H]RERFEMFREL 2
proximal
335C LQIRG[R/C]RERFEMFREL 2
proximal
334E LQIR[G/E]GRERFEMFREL 3
distal
334W LQIR[G/W]GRERFEMFREL 3
distal
334R LQIR[G/R]GRERFEMFREL 3
distal
333H LQI[R/H]RGRERFEMFREL 4
distal
333C LQI[R/C]RGRERFEMFREL 4
distal
332M LQ[I/M]IRGRERFEMFREL 5
distal
331R L[Q/R]QIRGRERFEMFREL 6
distal
331K L[Q/K]QIRGRERFEMFREL 6
distal
343Q LQIRGRERFEMFR[E/Q]EL 6
distal
334V LQIR[G/V]GRERFEMFREL 3
distal
331H L[Q/H]QIRGRERFEMFREL 6
distal
341L LQIRGRERFEM[F/L]FREL 4
distal
341V LQIRGRERFEM[F/V]FREL 4
distal
337S LQIRGRE[R/S]RFEMFREL 0
direct
338I LQIRGRER[F/I]FEMFREL 1
proximal
332F LQ[I/F]IRGRERFEMFREL 5
distal

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