TP53 R333C

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Mutation:

Summary

Isoform:

NM_000546

Position:

333

Ref:

Mutation:

PTM impact:

direct

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

Hereditary cancer-predisposing syndrome, Li-Fraumeni syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 327Y

Affected site:

Position: 327

Residue: Y

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
333H	KKPLDGEYFTLQI[R/H]RG	6	distal
333C	KKPLDGEYFTLQI[R/C]RG	6	distal
332M	KKPLDGEYFTLQ[I/M]IRG	5	distal
331R	KKPLDGEYFTL[Q/R]QIRG	4	distal
331K	KKPLDGEYFTL[Q/K]QIRG	4	distal
330P	KKPLDGEYFT[L/P]LQIRG	3	distal
329I	KKPLDGEYF[T/I]TLQIRG	2	proximal
329A	KKPLDGEYF[T/A]TLQIRG	2	proximal
328S	KKPLDGEY[F/S]FTLQIRG	1	proximal
325V	KKPLD[G/V]GEYFTLQIRG	2	proximal
325E	KKPLD[G/E]GEYFTLQIRG	2	proximal
325R	KKPLD[G/R]GEYFTLQIRG	2	proximal
324Y	KKPL[D/Y]DGEYFTLQIRG	3	network-rewiring
324H	KKPL[D/H]DGEYFTLQIRG	3	network-rewiring
323P	KKP[L/P]LDGEYFTLQIRG	4	distal
322S	KK[P/S]PLDGEYFTLQIRG	5	distal
322T	KK[P/T]PLDGEYFTLQIRG	5	distal
331H	KKPLDGEYFTL[Q/H]QIRG	4	distal
332F	KKPLDGEYFTLQ[I/F]IRG	5	distal

PTM Site: 333R

Affected site:

Position: 333

Residue: R

Type: methylation

Impact:

direct

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
339V	EYFTLQIRGRERF[E/V]EM	6	distal
339G	EYFTLQIRGRERF[E/G]EM	6	distal
339Q	EYFTLQIRGRERF[E/Q]EM	6	distal
339K	EYFTLQIRGRERF[E/K]EM	6	distal
338L	EYFTLQIRGRER[F/L]FEM	5	distal
338C	EYFTLQIRGRER[F/C]FEM	5	distal
337L	EYFTLQIRGRE[R/L]RFEM	4	distal
337P	EYFTLQIRGRE[R/P]RFEM	4	distal
337H	EYFTLQIRGRE[R/H]RFEM	4	distal
337C	EYFTLQIRGRE[R/C]RFEM	4	distal
337G	EYFTLQIRGRE[R/G]RFEM	4	distal
335P	EYFTLQIRG[R/P]RERFEM	2	proximal
335H	EYFTLQIRG[R/H]RERFEM	2	proximal
335C	EYFTLQIRG[R/C]RERFEM	2	proximal
334E	EYFTLQIR[G/E]GRERFEM	1	proximal
334W	EYFTLQIR[G/W]GRERFEM	1	proximal
334R	EYFTLQIR[G/R]GRERFEM	1	proximal
333H	EYFTLQI[R/H]RGRERFEM	0	direct
333C	EYFTLQI[R/C]RGRERFEM	0	direct
332M	EYFTLQ[I/M]IRGRERFEM	1	proximal
331R	EYFTL[Q/R]QIRGRERFEM	2	proximal
331K	EYFTL[Q/K]QIRGRERFEM	2	proximal
330P	EYFT[L/P]LQIRGRERFEM	3	distal
329I	EYF[T/I]TLQIRGRERFEM	4	distal
329A	EYF[T/A]TLQIRGRERFEM	4	distal
328S	EY[F/S]FTLQIRGRERFEM	5	distal
334V	EYFTLQIR[G/V]GRERFEM	1	proximal
331H	EYFTL[Q/H]QIRGRERFEM	2	proximal
337S	EYFTLQIRGRE[R/S]RFEM	4	distal
338I	EYFTLQIRGRER[F/I]FEM	5	distal
332F	EYFTLQ[I/F]IRGRERFEM	1	proximal

PTM Site: 335R

Affected site:

Position: 335

Residue: R

Type: methylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
340K	FTLQIRGRERFE[M/K]MFR	5	distal
339V	FTLQIRGRERF[E/V]EMFR	4	distal
339G	FTLQIRGRERF[E/G]EMFR	4	distal
339Q	FTLQIRGRERF[E/Q]EMFR	4	distal
339K	FTLQIRGRERF[E/K]EMFR	4	distal
338L	FTLQIRGRER[F/L]FEMFR	3	distal
338C	FTLQIRGRER[F/C]FEMFR	3	distal
337L	FTLQIRGRE[R/L]RFEMFR	2	proximal
337P	FTLQIRGRE[R/P]RFEMFR	2	proximal
337H	FTLQIRGRE[R/H]RFEMFR	2	proximal
337C	FTLQIRGRE[R/C]RFEMFR	2	proximal
337G	FTLQIRGRE[R/G]RFEMFR	2	proximal
335P	FTLQIRG[R/P]RERFEMFR	0	direct
335H	FTLQIRG[R/H]RERFEMFR	0	direct
335C	FTLQIRG[R/C]RERFEMFR	0	direct
334E	FTLQIR[G/E]GRERFEMFR	1	proximal
334W	FTLQIR[G/W]GRERFEMFR	1	proximal
334R	FTLQIR[G/R]GRERFEMFR	1	proximal
333H	FTLQI[R/H]RGRERFEMFR	2	proximal
333C	FTLQI[R/C]RGRERFEMFR	2	proximal
332M	FTLQ[I/M]IRGRERFEMFR	3	distal
331R	FTL[Q/R]QIRGRERFEMFR	4	distal
331K	FTL[Q/K]QIRGRERFEMFR	4	distal
330P	FT[L/P]LQIRGRERFEMFR	5	distal
329I	F[T/I]TLQIRGRERFEMFR	6	distal
329A	F[T/A]TLQIRGRERFEMFR	6	distal
334V	FTLQIR[G/V]GRERFEMFR	1	proximal
331H	FTL[Q/H]QIRGRERFEMFR	4	distal
341L	FTLQIRGRERFEM[F/L]FR	6	distal
341V	FTLQIRGRERFEM[F/V]FR	6	distal
337S	FTLQIRGRE[R/S]RFEMFR	2	proximal
338I	FTLQIRGRER[F/I]FEMFR	3	distal
332F	FTLQ[I/F]IRGRERFEMFR	3	distal

PTM Site: 337R

Affected site:

Position: 337

Residue: R

Type: methylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
342P	LQIRGRERFEMF[R/P]REL	5	distal
342Q	LQIRGRERFEMF[R/Q]REL	5	distal
340K	LQIRGRERFE[M/K]MFREL	3	distal
339V	LQIRGRERF[E/V]EMFREL	2	proximal
339G	LQIRGRERF[E/G]EMFREL	2	proximal
339Q	LQIRGRERF[E/Q]EMFREL	2	proximal
339K	LQIRGRERF[E/K]EMFREL	2	proximal
338L	LQIRGRER[F/L]FEMFREL	1	proximal
338C	LQIRGRER[F/C]FEMFREL	1	proximal
337L	LQIRGRE[R/L]RFEMFREL	0	direct
337P	LQIRGRE[R/P]RFEMFREL	0	direct
337H	LQIRGRE[R/H]RFEMFREL	0	direct
337C	LQIRGRE[R/C]RFEMFREL	0	direct
337G	LQIRGRE[R/G]RFEMFREL	0	direct
335P	LQIRG[R/P]RERFEMFREL	2	proximal
335H	LQIRG[R/H]RERFEMFREL	2	proximal
335C	LQIRG[R/C]RERFEMFREL	2	proximal
334E	LQIR[G/E]GRERFEMFREL	3	distal
334W	LQIR[G/W]GRERFEMFREL	3	distal
334R	LQIR[G/R]GRERFEMFREL	3	distal
333H	LQI[R/H]RGRERFEMFREL	4	distal
333C	LQI[R/C]RGRERFEMFREL	4	distal
332M	LQ[I/M]IRGRERFEMFREL	5	distal
331R	L[Q/R]QIRGRERFEMFREL	6	distal
331K	L[Q/K]QIRGRERFEMFREL	6	distal
343Q	LQIRGRERFEMFR[E/Q]EL	6	distal
334V	LQIR[G/V]GRERFEMFREL	3	distal
331H	L[Q/H]QIRGRERFEMFREL	6	distal
341L	LQIRGRERFEM[F/L]FREL	4	distal
341V	LQIRGRERFEM[F/V]FREL	4	distal
337S	LQIRGRE[R/S]RFEMFREL	0	direct
338I	LQIRGRER[F/I]FEMFREL	1	proximal
332F	LQ[I/F]IRGRERFEMFREL	5	distal

External references

dbSNP:

rs769934890

If you have any questions or feedback about this mutation: