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Mutation:
TP53 R333C
Summary
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Hereditary cancer-predisposing syndrome, Li-Fraumeni syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 327Y
Affected site:
Position: 327
Residue: Y
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 328S | KKPLDGEY[F/S]FTLQIRG | 1 |
proximal
|
| 329I | KKPLDGEYF[T/I]TLQIRG | 2 |
proximal
|
| 329A | KKPLDGEYF[T/A]TLQIRG | 2 |
proximal
|
| 325V | KKPLD[G/V]GEYFTLQIRG | 2 |
proximal
|
| 325E | KKPLD[G/E]GEYFTLQIRG | 2 |
proximal
|
PTM Site: 333R
Affected site:
Position: 333
Residue: R
Type: methylation
Impact:
directOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 333H | EYFTLQI[R/H]RGRERFEM | 0 |
direct
|
| 333C | EYFTLQI[R/C]RGRERFEM | 0 |
direct
|
| 334E | EYFTLQIR[G/E]GRERFEM | 1 |
proximal
|
| 334W | EYFTLQIR[G/W]GRERFEM | 1 |
proximal
|
| 334R | EYFTLQIR[G/R]GRERFEM | 1 |
proximal
|
PTM Site: 335R
Affected site:
Position: 335
Residue: R
Type: methylation
Impact:
proximalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 335P | FTLQIRG[R/P]RERFEMFR | 0 |
direct
|
| 335H | FTLQIRG[R/H]RERFEMFR | 0 |
direct
|
| 335C | FTLQIRG[R/C]RERFEMFR | 0 |
direct
|
| 334E | FTLQIR[G/E]GRERFEMFR | 1 |
proximal
|
| 334W | FTLQIR[G/W]GRERFEMFR | 1 |
proximal
|
PTM Site: 337R
Affected site:
Position: 337
Residue: R
Type: methylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 337L | LQIRGRE[R/L]RFEMFREL | 0 |
direct
|
| 337P | LQIRGRE[R/P]RFEMFREL | 0 |
direct
|
| 337H | LQIRGRE[R/H]RFEMFREL | 0 |
direct
|
| 337C | LQIRGRE[R/C]RFEMFREL | 0 |
direct
|
| 337G | LQIRGRE[R/G]RFEMFREL | 0 |
direct
|
External references
dbSNP:
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