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Mutation:
TP53 R282W
Summary
Isoform:
Position:
282
Ref:
R
Mutation:
W
PTM impact:
network-rewiring
PTM affected:
1
Kinases:
AURKB
Clinical Information
Cancer types: (TCGA MC3)
COAD, PAAD, BRCA, PRAD, GBM, KICH, READ, UCEC, LUAD, ESCA, HNSC, STAD, LUSC, LGG, BLCA
Disease Annotations: (ClinVar)
Li-Fraumeni-like syndrome, Hereditary cancer-predisposing syndrome, Li-Fraumeni syndrome 1, Li-Fraumeni syndrome
Minor Allele Frequency: (ESP6500)
[0.0154]
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 284T
Affected site:
Position: 284
Residue: T
Type: phosphorylation
Best loss of PTM site:
AURKB (probability p=0.893)
Site: 284T (phosphorylation)
Position in motif: -2
There are 2 other predicted
losses:
- ROCK1 (p=0.874)
- PRKACA (p=0.869)
Other known mutations affecting this site
External references
dbSNP:
If you have any questions or feedback about this mutation:
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