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Mutation:
TP53 T284I
Summary
Isoform:
Position:
284
Ref:
T
Mutation:
I
PTM impact:
direct
PTM affected:
3
Kinases:
AURKB
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Li-Fraumeni syndrome, Hereditary cancer-predisposing syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 284T
Affected site:
Position: 284
Residue: T
Type: phosphorylation
Impact:
directOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 284I | CPGRDRR[T/I]TEEENLRK | 0 |
direct
|
| 284S | CPGRDRR[T/S]TEEENLRK | 0 |
direct
|
| 284A | CPGRDRR[T/A]TEEENLRK | 0 |
direct
|
| 284P | CPGRDRR[T/P]TEEENLRK | 0 |
direct
|
| 285V | CPGRDRRT[E/V]EEENLRK | 1 |
proximal
|
PTM Site: 290R
Affected site:
Position: 290
Residue: R
Type: methylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 290L | RTEEENL[R/L]RKKGEPHH | 0 |
direct
|
| 290P | RTEEENL[R/P]RKKGEPHH | 0 |
direct
|
| 290H | RTEEENL[R/H]RKKGEPHH | 0 |
direct
|
| 290C | RTEEENL[R/C]RKKGEPHH | 0 |
direct
|
| 290G | RTEEENL[R/G]RKKGEPHH | 0 |
direct
|
PTM Site: 291K
Affected site:
Position: 291
Residue: K
Type: ubiquitination
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 291N | TEEENLR[K/N]KKGEPHHE | 0 |
direct
|
| 291E | TEEENLR[K/E]KKGEPHHE | 0 |
direct
|
| 292I | TEEENLRK[K/I]KGEPHHE | 1 |
proximal
|
| 292R | TEEENLRK[K/R]KGEPHHE | 1 |
proximal
|
| 290L | TEEENL[R/L]RKKGEPHHE | 1 |
proximal
|
External references
dbSNP:
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