TP53 D281N

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Mutation:

Summary

Isoform:

NM_000546

Position:

281

Ref:

Mutation:

PTM impact:

distal

PTM affected:

Kinases:

AURKB

Clinical Information

Cancer types: (TCGA MC3)

LUAD, UCS

Cancer types: (PCAWG)

Lymph-BNHL, Panc-AdenoCA, Stomach-AdenoCA

Disease Annotations: (ClinVar)

Li-Fraumeni syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 284T

Affected site:

Position: 284

Residue: T

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
290L	CPGRDRRTEEENL[R/L]RK	6	distal
290P	CPGRDRRTEEENL[R/P]RK	6	distal
290H	CPGRDRRTEEENL[R/H]RK	6	distal
290C	CPGRDRRTEEENL[R/C]RK	6	distal
290G	CPGRDRRTEEENL[R/G]RK	6	distal
289F	CPGRDRRTEEEN[L/F]LRK	5	distal
287D	CPGRDRRTEE[E/D]ENLRK	3	distal
287K	CPGRDRRTEE[E/K]ENLRK	3	network-rewiring
286V	CPGRDRRTE[E/V]EENLRK	2	proximal
286G	CPGRDRRTE[E/G]EENLRK	2	proximal
286A	CPGRDRRTE[E/A]EENLRK	2	proximal
286Q	CPGRDRRTE[E/Q]EENLRK	2	proximal
286K	CPGRDRRTE[E/K]EENLRK	2	network-rewiring
285V	CPGRDRRT[E/V]EEENLRK	1	proximal
285G	CPGRDRRT[E/G]EEENLRK	1	proximal
285Q	CPGRDRRT[E/Q]EEENLRK	1	network-rewiring
285K	CPGRDRRT[E/K]EEENLRK	1	proximal
284I	CPGRDRR[T/I]TEEENLRK	0	direct
284S	CPGRDRR[T/S]TEEENLRK	0	direct
284A	CPGRDRR[T/A]TEEENLRK	0	direct
283P	CPGRDR[R/P]RTEEENLRK	1	proximal
283H	CPGRDR[R/H]RTEEENLRK	1	proximal
283C	CPGRDR[R/C]RTEEENLRK	1	proximal
283G	CPGRDR[R/G]RTEEENLRK	1	proximal
282L	CPGRD[R/L]RRTEEENLRK	2	network-rewiring
282P	CPGRD[R/P]RRTEEENLRK	2	network-rewiring
282Q	CPGRD[R/Q]RRTEEENLRK	2	network-rewiring
282W	CPGRD[R/W]RRTEEENLRK	2	network-rewiring
282G	CPGRD[R/G]RRTEEENLRK	2	network-rewiring
281E	CPGR[D/E]DRRTEEENLRK	3	distal
281V	CPGR[D/V]DRRTEEENLRK	3	distal
281G	CPGR[D/G]DRRTEEENLRK	3	distal
281A	CPGR[D/A]DRRTEEENLRK	3	distal
281Y	CPGR[D/Y]DRRTEEENLRK	3	distal
281H	CPGR[D/H]DRRTEEENLRK	3	distal
281N	CPGR[D/N]DRRTEEENLRK	3	distal
280S	CPG[R/S]RDRRTEEENLRK	4	distal
280I	CPG[R/I]RDRRTEEENLRK	4	distal
280T	CPG[R/T]RDRRTEEENLRK	4	distal
280K	CPG[R/K]RDRRTEEENLRK	4	distal
280G	CPG[R/G]RDRRTEEENLRK	4	distal
279E	CP[G/E]GRDRRTEEENLRK	5	distal
279R	CP[G/R]GRDRRTEEENLRK	5	network-rewiring
278L	C[P/L]PGRDRRTEEENLRK	6	distal
278R	C[P/R]PGRDRRTEEENLRK	6	distal
278H	C[P/H]PGRDRRTEEENLRK	6	distal
278S	C[P/S]PGRDRRTEEENLRK	6	distal
278A	C[P/A]PGRDRRTEEENLRK	6	distal
278T	C[P/T]PGRDRRTEEENLRK	6	distal
284P	CPGRDRR[T/P]TEEENLRK	0	direct
287Q	CPGRDRRTEE[E/Q]ENLRK	3	network-rewiring

External references

dbSNP:

rs764146326

If you have any questions or feedback about this mutation: