1. Home
  2. Pathways
  3. REAC: 5633007
Login

After several years of serving the research community, our ActiveDriverDB database will be retired on May 1st 2026. Please make sure to download any data you need and update your links or workflows before that date.

We want to sincerely thank all our users for their support, feedback, and collaboration over the years — your contributions have been invaluable to this project. A special thank you to Dr. Michal Krassowski for leading the development of our open-source software and database.

For any questions or assistance, please contact Jüri Reimand (juri.reimand@utoronto.ca).

You are viewing an old version (2017) of the ActiveDriverDB. To access the new (2020) version click here.

Regulation of TP53 Activity

Genes involved in this pathway:

Gene name Summary # mutations # PTM mutations # PTM sites
XXBAC-BPG32J3.22 - - - -
CCNA2 cyclin A2 48 12 11
PRDM1 PR/SET domain 1 139 18 10
ATR ATR serine/threonine kinase 360 65 35
ZNF385A zinc finger protein 385A 47 16 7
PPP2R1B protein phosphatase 2 scaffold subunit Abeta 85 37 21
PPP1R13B protein phosphatase 1 regulatory subunit 13B 159 10 12
PRKAG3 protein kinase AMP-activated non-catalytic subunit gamma 3 107 0 0
CHEK2 checkpoint kinase 2 356 149 42
STK11 serine/threonine kinase 11 217 115 23
TAF3 TATA-box binding protein associated factor 3 119 56 46
BRD7 bromodomain containing 7 94 25 18
BLM Bloom syndrome RecQ like helicase 236 102 81
CSNK2B casein kinase 2 beta 16 5 18
EP300 E1A binding protein p300 363 126 120
SGK1 serum/glucocorticoid regulated kinase 1 57 17 9
CSNK2A2 casein kinase 2 alpha 2 29 12 12
MDM2 MDM2 proto-oncogene 53 37 47
TAF7 TATA-box binding protein associated factor 7 36 14 17
KMT5A lysine methyltransferase 5A 38 10 10
TOP3A topoisomerase (DNA) III alpha 158 11 7
RAD9A RAD9 checkpoint clamp component A 82 28 16
SETD9 SET domain containing 9 40 0 0
RFC5 replication factor C subunit 5 41 20 12
TAF6 TATA-box binding protein associated factor 6 89 27 21
RMI2 RecQ mediated genome instability 2 15 2 3
TAF9 TATA-box binding protein associated factor 9 31 18 24
DAXX death domain associated protein 120 68 56
CDKN2A cyclin dependent kinase inhibitor 2A 144 32 5
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma 61 13 8
AURKA aurora kinase A 46 29 26
BANP BTG3 associated nuclear protein 64 11 9
CHD3 chromodomain helicase DNA binding protein 3 214 46 50
TAF13 TATA-box binding protein associated factor 13 13 3 2
PPP1R13L protein phosphatase 1 regulatory subunit 13 like 119 69 66
RFC2 replication factor C subunit 2 53 23 13
RFC4 replication factor C subunit 4 80 23 19
HIPK1 homeodomain interacting protein kinase 1 139 29 22
TAF5 TATA-box binding protein associated factor 5 72 0 1
CSNK2A1 casein kinase 2 alpha 1 40 28 31
BRIP1 BRCA1 interacting protein C-terminal helicase 1 455 172 46
PRR5 proline rich 5 74 18 12
RAD17 RAD17 checkpoint clamp loader component 106 18 11
RBBP7 RB binding protein 7, chromatin remodeling factor 38 13 24
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 57 9 8
MAP2K6 mitogen-activated protein kinase kinase 6 31 8 11
TTC5 tetratricopeptide repeat domain 5 64 0 1
UBB ubiquitin B 9 9 48
PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 35 9 7
PDPK1 3-phosphoinositide dependent protein kinase 1 37 17 31
SUPT16H SPT16 homolog, facilitates chromatin remodeling subunit 104 56 66
BARD1 BRCA1 associated RING domain 1 386 122 25
PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1 37 22 23
PRMT5 protein arginine methyltransferase 5 65 14 15
MLST8 MTOR associated protein, LST8 homolog 38 2 5
RNF34 ring finger protein 34 46 7 10
HUS1 HUS1 checkpoint clamp component 40 7 4
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 16 11 19
PRKAG2 protein kinase AMP-activated non-catalytic subunit gamma 2 117 61 39
AKT3 AKT serine/threonine kinase 3 63 21 15
RBBP8 RB binding protein 8, endonuclease 123 43 34
TAF4B TATA-box binding protein associated factor 4b 125 10 7
TMEM55B transmembrane protein 55B 33 4 5
BRPF3 bromodomain and PHD finger containing 3 150 40 32
USP7 ubiquitin specific peptidase 7 115 32 26
POU4F2 POU class 4 homeobox 2 99 0 0
TAF7L TATA-box binding protein associated factor 7 like 73 2 3
RBBP4 RB binding protein 4, chromatin remodeling factor 32 11 17
POU4F1 POU class 4 homeobox 1 40 1 3
TAF4 TATA-box binding protein associated factor 4 93 29 16
HDAC2 histone deacetylase 2 33 11 27
CCNG1 cyclin G1 38 0 0
CHD4 chromodomain helicase DNA binding protein 4 253 96 93
PML promyelocytic leukemia 135 41 48
MDM4 MDM4, p53 regulator 55 18 11
TP53BP2 tumor protein p53 binding protein 2 174 59 39
DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 77 9 11
L3MBTL1 L3MBTL1, histone methyl-lysine binding protein 151 3 2
MAPK14 mitogen-activated protein kinase 14 27 9 20
MTA2 metastasis associated 1 family member 2 77 35 35
TOPBP1 topoisomerase (DNA) II binding protein 1 208 52 40
EHMT2 euchromatic histone lysine methyltransferase 2 147 42 40
RFC3 replication factor C subunit 3 51 21 13
AKT1 AKT serine/threonine kinase 1 57 27 33
WRN Werner syndrome RecQ like helicase 268 55 31
TAF2 TATA-box binding protein associated factor 2 134 19 18
PPP2R1A protein phosphatase 2 scaffold subunit Aalpha 94 54 30
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase type 2 beta 45 7 10
BRD1 bromodomain containing 1 163 57 43
TAF10 TATA-box binding protein associated factor 10 20 1 5
RAD1 RAD1 checkpoint DNA exonuclease 39 4 3
KAT6A lysine acetyltransferase 6A 282 77 42
PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 98 19 13
RMI1 RecQ mediated genome instability 1 84 15 16
TAF11 TATA-box binding protein associated factor 11 27 6 3
RPS27A ribosomal protein S27a 14 13 24
UBC ubiquitin C 79 75 143
TP63 tumor protein p63 171 43 17
PPP2CA protein phosphatase 2 catalytic subunit alpha 24 16 19
PHF20 PHD finger protein 20 150 33 20
CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 24 1 3
MTOR mechanistic target of rapamycin 300 47 53
GATAD2A GATA zinc finger domain containing 2A 113 75 50
MEAF6 MYST/Esa1 associated factor 6 17 11 13
ATM ATM serine/threonine kinase 1334 230 54
TPX2 TPX2, microtubule nucleation factor 104 70 64
CDK1 cyclin dependent kinase 1 23 22 37
NUAK1 NUAK family kinase 1 114 23 12
RPA3 replication protein A3 17 1 4
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha 53 10 10
RICTOR RPTOR independent companion of MTOR complex 2 193 60 99
BRPF1 bromodomain and PHD finger containing 1 148 45 37
SMYD2 SET and MYND domain containing 2 54 0 1
DNA2 DNA replication helicase/nuclease 2 136 35 22
AURKB aurora kinase B 57 38 31
MBD3 methyl-CpG binding domain protein 3 56 15 14
PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2 21 9 16
NBN nibrin 297 141 52
TP53INP1 tumor protein p53 inducible nuclear protein 1 41 0 1
RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 40 6 4
PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 63 34 39
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 18 8 14
GATAD2B GATA zinc finger domain containing 2B 77 36 33
TP53RK TP53 regulating kinase 28 11 9
CDK5 cyclin dependent kinase 5 33 13 15
SSRP1 structure specific recognition protein 1 77 59 65
NOC2L NOC2 like nucleolar associated transcriptional repressor 162 75 44
TAF1L TATA-box binding protein associated factor 1 like 467 27 7
RAD50 RAD50 double strand break repair protein 466 130 35
HDAC1 histone deacetylase 1 45 27 36
CDK2 cyclin dependent kinase 2 23 14 23
BRCA1 BRCA1, DNA repair associated 1443 532 80
EXO1 exonuclease 1 181 87 33
RAD9B RAD9 checkpoint clamp component B 63 0 1
TBP TATA-box binding protein 33 9 6
TAF9B TATA-box binding protein associated factor 9b 38 22 15
TAF12 TATA-box binding protein associated factor 12 16 6 3
EHMT1 euchromatic histone lysine methyltransferase 1 225 69 32
RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 51 9 12
MAPK11 mitogen-activated protein kinase 11 34 9 7
CHEK1 checkpoint kinase 1 55 28 34
ING5 inhibitor of growth family member 5 22 11 11
JMY junction mediating and regulatory protein, p53 cofactor 111 13 16
TAF1 TATA-box binding protein associated factor 1 232 20 28
AKT2 AKT serine/threonine kinase 2 75 27 24
RPA1 replication protein A1 83 51 48
USP2 ubiquitin specific peptidase 2 108 5 3
PLK3 polo like kinase 3 98 5 7
PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 63 15 11
ATRIP ATR interacting protein 117 23 19
ING2 inhibitor of growth family member 2 31 0 1
MRE11A MRE11 homolog, double strand break repair nuclease 280 137 51
RPA2 replication protein A2 36 23 23
MAPKAP1 mitogen-activated protein kinase associated protein 1 70 17 12
HIPK2 homeodomain interacting protein kinase 2 159 43 31
CCNA1 cyclin A1 87 0 0
PPP2CB protein phosphatase 2 catalytic subunit beta 26 14 15
KAT5 lysine acetyltransferase 5 54 19 20
TP73 tumor protein p73 106 30 14
TP53 tumor protein p53 591 443 61