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Regulation of TP53 Activity
Genes involved in this pathway:
Gene name | Summary | # mutations | # PTM mutations | # PTM sites |
---|---|---|---|---|
XXBAC-BPG32J3.22 | - | - | - | - |
CCNA2 | cyclin A2 | 48 | 12 | 11 |
PRDM1 | PR/SET domain 1 | 139 | 18 | 10 |
ATR | ATR serine/threonine kinase | 360 | 65 | 35 |
ZNF385A | zinc finger protein 385A | 47 | 16 | 7 |
PPP2R1B | protein phosphatase 2 scaffold subunit Abeta | 85 | 37 | 21 |
PPP1R13B | protein phosphatase 1 regulatory subunit 13B | 159 | 10 | 12 |
PRKAG3 | protein kinase AMP-activated non-catalytic subunit gamma 3 | 107 | 0 | 0 |
CHEK2 | checkpoint kinase 2 | 356 | 149 | 42 |
STK11 | serine/threonine kinase 11 | 217 | 115 | 23 |
TAF3 | TATA-box binding protein associated factor 3 | 119 | 56 | 46 |
BRD7 | bromodomain containing 7 | 94 | 25 | 18 |
BLM | Bloom syndrome RecQ like helicase | 236 | 102 | 81 |
CSNK2B | casein kinase 2 beta | 16 | 5 | 18 |
EP300 | E1A binding protein p300 | 363 | 126 | 120 |
SGK1 | serum/glucocorticoid regulated kinase 1 | 57 | 17 | 9 |
CSNK2A2 | casein kinase 2 alpha 2 | 29 | 12 | 12 |
MDM2 | MDM2 proto-oncogene | 53 | 37 | 47 |
TAF7 | TATA-box binding protein associated factor 7 | 36 | 14 | 17 |
KMT5A | lysine methyltransferase 5A | 38 | 10 | 10 |
TOP3A | topoisomerase (DNA) III alpha | 158 | 11 | 7 |
RAD9A | RAD9 checkpoint clamp component A | 82 | 28 | 16 |
SETD9 | SET domain containing 9 | 40 | 0 | 0 |
RFC5 | replication factor C subunit 5 | 41 | 20 | 12 |
TAF6 | TATA-box binding protein associated factor 6 | 89 | 27 | 21 |
RMI2 | RecQ mediated genome instability 2 | 15 | 2 | 3 |
TAF9 | TATA-box binding protein associated factor 9 | 31 | 18 | 24 |
DAXX | death domain associated protein | 120 | 68 | 56 |
CDKN2A | cyclin dependent kinase inhibitor 2A | 144 | 32 | 5 |
PIP4K2C | phosphatidylinositol-5-phosphate 4-kinase type 2 gamma | 61 | 13 | 8 |
AURKA | aurora kinase A | 46 | 29 | 26 |
BANP | BTG3 associated nuclear protein | 64 | 11 | 9 |
CHD3 | chromodomain helicase DNA binding protein 3 | 214 | 46 | 50 |
TAF13 | TATA-box binding protein associated factor 13 | 13 | 3 | 2 |
PPP1R13L | protein phosphatase 1 regulatory subunit 13 like | 119 | 69 | 66 |
RFC2 | replication factor C subunit 2 | 53 | 23 | 13 |
RFC4 | replication factor C subunit 4 | 80 | 23 | 19 |
HIPK1 | homeodomain interacting protein kinase 1 | 139 | 29 | 22 |
TAF5 | TATA-box binding protein associated factor 5 | 72 | 0 | 1 |
CSNK2A1 | casein kinase 2 alpha 1 | 40 | 28 | 31 |
BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 455 | 172 | 46 |
PRR5 | proline rich 5 | 74 | 18 | 12 |
RAD17 | RAD17 checkpoint clamp loader component | 106 | 18 | 11 |
RBBP7 | RB binding protein 7, chromatin remodeling factor | 38 | 13 | 24 |
MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 57 | 9 | 8 |
MAP2K6 | mitogen-activated protein kinase kinase 6 | 31 | 8 | 11 |
TTC5 | tetratricopeptide repeat domain 5 | 64 | 0 | 1 |
UBB | ubiquitin B | 9 | 9 | 48 |
PRKAG1 | protein kinase AMP-activated non-catalytic subunit gamma 1 | 35 | 9 | 7 |
PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 37 | 17 | 31 |
SUPT16H | SPT16 homolog, facilitates chromatin remodeling subunit | 104 | 56 | 66 |
BARD1 | BRCA1 associated RING domain 1 | 386 | 122 | 25 |
PRKAB1 | protein kinase AMP-activated non-catalytic subunit beta 1 | 37 | 22 | 23 |
PRMT5 | protein arginine methyltransferase 5 | 65 | 14 | 15 |
MLST8 | MTOR associated protein, LST8 homolog | 38 | 2 | 5 |
RNF34 | ring finger protein 34 | 46 | 7 | 10 |
HUS1 | HUS1 checkpoint clamp component | 40 | 7 | 4 |
UBA52 | ubiquitin A-52 residue ribosomal protein fusion product 1 | 16 | 11 | 19 |
PRKAG2 | protein kinase AMP-activated non-catalytic subunit gamma 2 | 117 | 61 | 39 |
AKT3 | AKT serine/threonine kinase 3 | 63 | 21 | 15 |
RBBP8 | RB binding protein 8, endonuclease | 123 | 43 | 34 |
TAF4B | TATA-box binding protein associated factor 4b | 125 | 10 | 7 |
TMEM55B | transmembrane protein 55B | 33 | 4 | 5 |
BRPF3 | bromodomain and PHD finger containing 3 | 150 | 40 | 32 |
USP7 | ubiquitin specific peptidase 7 | 115 | 32 | 26 |
POU4F2 | POU class 4 homeobox 2 | 99 | 0 | 0 |
TAF7L | TATA-box binding protein associated factor 7 like | 73 | 2 | 3 |
RBBP4 | RB binding protein 4, chromatin remodeling factor | 32 | 11 | 17 |
POU4F1 | POU class 4 homeobox 1 | 40 | 1 | 3 |
TAF4 | TATA-box binding protein associated factor 4 | 93 | 29 | 16 |
HDAC2 | histone deacetylase 2 | 33 | 11 | 27 |
CCNG1 | cyclin G1 | 38 | 0 | 0 |
CHD4 | chromodomain helicase DNA binding protein 4 | 253 | 96 | 93 |
PML | promyelocytic leukemia | 135 | 41 | 48 |
MDM4 | MDM4, p53 regulator | 55 | 18 | 11 |
TP53BP2 | tumor protein p53 binding protein 2 | 174 | 59 | 39 |
DYRK2 | dual specificity tyrosine phosphorylation regulated kinase 2 | 77 | 9 | 11 |
L3MBTL1 | L3MBTL1, histone methyl-lysine binding protein | 151 | 3 | 2 |
MAPK14 | mitogen-activated protein kinase 14 | 27 | 9 | 20 |
MTA2 | metastasis associated 1 family member 2 | 77 | 35 | 35 |
TOPBP1 | topoisomerase (DNA) II binding protein 1 | 208 | 52 | 40 |
EHMT2 | euchromatic histone lysine methyltransferase 2 | 147 | 42 | 40 |
RFC3 | replication factor C subunit 3 | 51 | 21 | 13 |
AKT1 | AKT serine/threonine kinase 1 | 57 | 27 | 33 |
WRN | Werner syndrome RecQ like helicase | 268 | 55 | 31 |
TAF2 | TATA-box binding protein associated factor 2 | 134 | 19 | 18 |
PPP2R1A | protein phosphatase 2 scaffold subunit Aalpha | 94 | 54 | 30 |
PIP4K2B | phosphatidylinositol-5-phosphate 4-kinase type 2 beta | 45 | 7 | 10 |
BRD1 | bromodomain containing 1 | 163 | 57 | 43 |
TAF10 | TATA-box binding protein associated factor 10 | 20 | 1 | 5 |
RAD1 | RAD1 checkpoint DNA exonuclease | 39 | 4 | 3 |
KAT6A | lysine acetyltransferase 6A | 282 | 77 | 42 |
PRKAA2 | protein kinase AMP-activated catalytic subunit alpha 2 | 98 | 19 | 13 |
RMI1 | RecQ mediated genome instability 1 | 84 | 15 | 16 |
TAF11 | TATA-box binding protein associated factor 11 | 27 | 6 | 3 |
RPS27A | ribosomal protein S27a | 14 | 13 | 24 |
UBC | ubiquitin C | 79 | 75 | 143 |
TP63 | tumor protein p63 | 171 | 43 | 17 |
PPP2CA | protein phosphatase 2 catalytic subunit alpha | 24 | 16 | 19 |
PHF20 | PHD finger protein 20 | 150 | 33 | 20 |
CDK5R1 | cyclin dependent kinase 5 regulatory subunit 1 | 24 | 1 | 3 |
MTOR | mechanistic target of rapamycin | 300 | 47 | 53 |
GATAD2A | GATA zinc finger domain containing 2A | 113 | 75 | 50 |
MEAF6 | MYST/Esa1 associated factor 6 | 17 | 11 | 13 |
ATM | ATM serine/threonine kinase | 1334 | 230 | 54 |
TPX2 | TPX2, microtubule nucleation factor | 104 | 70 | 64 |
CDK1 | cyclin dependent kinase 1 | 23 | 22 | 37 |
NUAK1 | NUAK family kinase 1 | 114 | 23 | 12 |
RPA3 | replication protein A3 | 17 | 1 | 4 |
PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase type 2 alpha | 53 | 10 | 10 |
RICTOR | RPTOR independent companion of MTOR complex 2 | 193 | 60 | 99 |
BRPF1 | bromodomain and PHD finger containing 1 | 148 | 45 | 37 |
SMYD2 | SET and MYND domain containing 2 | 54 | 0 | 1 |
DNA2 | DNA replication helicase/nuclease 2 | 136 | 35 | 22 |
AURKB | aurora kinase B | 57 | 38 | 31 |
MBD3 | methyl-CpG binding domain protein 3 | 56 | 15 | 14 |
PRKAB2 | protein kinase AMP-activated non-catalytic subunit beta 2 | 21 | 9 | 16 |
NBN | nibrin | 297 | 141 | 52 |
TP53INP1 | tumor protein p53 inducible nuclear protein 1 | 41 | 0 | 1 |
RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1 | 40 | 6 | 4 |
PRKAA1 | protein kinase AMP-activated catalytic subunit alpha 1 | 63 | 34 | 39 |
PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | 18 | 8 | 14 |
GATAD2B | GATA zinc finger domain containing 2B | 77 | 36 | 33 |
TP53RK | TP53 regulating kinase | 28 | 11 | 9 |
CDK5 | cyclin dependent kinase 5 | 33 | 13 | 15 |
SSRP1 | structure specific recognition protein 1 | 77 | 59 | 65 |
NOC2L | NOC2 like nucleolar associated transcriptional repressor | 162 | 75 | 44 |
TAF1L | TATA-box binding protein associated factor 1 like | 467 | 27 | 7 |
RAD50 | RAD50 double strand break repair protein | 466 | 130 | 35 |
HDAC1 | histone deacetylase 1 | 45 | 27 | 36 |
CDK2 | cyclin dependent kinase 2 | 23 | 14 | 23 |
BRCA1 | BRCA1, DNA repair associated | 1443 | 532 | 80 |
EXO1 | exonuclease 1 | 181 | 87 | 33 |
RAD9B | RAD9 checkpoint clamp component B | 63 | 0 | 1 |
TBP | TATA-box binding protein | 33 | 9 | 6 |
TAF9B | TATA-box binding protein associated factor 9b | 38 | 22 | 15 |
TAF12 | TATA-box binding protein associated factor 12 | 16 | 6 | 3 |
EHMT1 | euchromatic histone lysine methyltransferase 1 | 225 | 69 | 32 |
RFFL | ring finger and FYVE like domain containing E3 ubiquitin protein ligase | 51 | 9 | 12 |
MAPK11 | mitogen-activated protein kinase 11 | 34 | 9 | 7 |
CHEK1 | checkpoint kinase 1 | 55 | 28 | 34 |
ING5 | inhibitor of growth family member 5 | 22 | 11 | 11 |
JMY | junction mediating and regulatory protein, p53 cofactor | 111 | 13 | 16 |
TAF1 | TATA-box binding protein associated factor 1 | 232 | 20 | 28 |
AKT2 | AKT serine/threonine kinase 2 | 75 | 27 | 24 |
RPA1 | replication protein A1 | 83 | 51 | 48 |
USP2 | ubiquitin specific peptidase 2 | 108 | 5 | 3 |
PLK3 | polo like kinase 3 | 98 | 5 | 7 |
PPP2R5C | protein phosphatase 2 regulatory subunit B'gamma | 63 | 15 | 11 |
ATRIP | ATR interacting protein | 117 | 23 | 19 |
ING2 | inhibitor of growth family member 2 | 31 | 0 | 1 |
MRE11A | MRE11 homolog, double strand break repair nuclease | 280 | 137 | 51 |
RPA2 | replication protein A2 | 36 | 23 | 23 |
MAPKAP1 | mitogen-activated protein kinase associated protein 1 | 70 | 17 | 12 |
HIPK2 | homeodomain interacting protein kinase 2 | 159 | 43 | 31 |
CCNA1 | cyclin A1 | 87 | 0 | 0 |
PPP2CB | protein phosphatase 2 catalytic subunit beta | 26 | 14 | 15 |
KAT5 | lysine acetyltransferase 5 | 54 | 19 | 20 |
TP73 | tumor protein p73 | 106 | 30 | 14 |
TP53 | tumor protein p53 | 591 | 443 | 61 |