You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
TP53 G293W
Summary
Isoform:
Position:
293
Ref:
G
Mutation:
W
PTM impact:
proximal
PTM affected:
3
Kinases:
EP300
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Hereditary cancer-predisposing syndrome, Li-Fraumeni syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 290R
Affected site:
Position: 290
Residue: R
Type: methylation
Impact:
distalOther known mutations affecting this site
Loading, please wait...
Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 290L | RTEEENL[R/L]RKKGEPHH | 0 |
direct
|
| 290P | RTEEENL[R/P]RKKGEPHH | 0 |
direct
|
| 290H | RTEEENL[R/H]RKKGEPHH | 0 |
direct
|
| 290C | RTEEENL[R/C]RKKGEPHH | 0 |
direct
|
| 290G | RTEEENL[R/G]RKKGEPHH | 0 |
direct
|
PTM Site: 291K
Affected site:
Position: 291
Residue: K
Type: ubiquitination
Impact:
proximalOther known mutations affecting this site
Loading, please wait...
Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 291N | TEEENLR[K/N]KKGEPHHE | 0 |
direct
|
| 291E | TEEENLR[K/E]KKGEPHHE | 0 |
direct
|
| 292I | TEEENLRK[K/I]KGEPHHE | 1 |
proximal
|
| 292R | TEEENLRK[K/R]KGEPHHE | 1 |
proximal
|
| 290L | TEEENL[R/L]RKKGEPHHE | 1 |
proximal
|
PTM Site: 292K
Affected site:
Position: 292
Residue: K
Type: acetylation, ubiquitination
Impact:
proximalOther known mutations affecting this site
Loading, please wait...
Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 292I | EEENLRK[K/I]KGEPHHEL | 0 |
direct
|
| 292R | EEENLRK[K/R]KGEPHHEL | 0 |
direct
|
| 293W | EEENLRKK[G/W]GEPHHEL | 1 |
proximal
|
| 293R | EEENLRKK[G/R]GEPHHEL | 1 |
proximal
|
| 291N | EEENLR[K/N]KKGEPHHEL | 1 |
proximal
|
External references
dbSNP:
If you have any questions or feedback about this mutation:
Contact us