ActiveDriverDB'20

Find your mutation or gene of interest

Examples results:

Advanced protein search Advanced mutation search

You are viewing an older version (2020) of the ActiveDriverDB. To view the current (2021) version please visit activedriverdb.org

39,159

Proteins

3,707,271

Mutations

18,511

Pathways

544,720

PTM sites

What is ActiveDriverDB?

ActiveDriverDB is a human proteo-genomics database. The database uses information about post-translational modifications (PTMs) in proteins to annotate and interpret genetic variation, disease genes, and cancer driver genes. All datasets in ActiveDriverDB is collected from public resources and based on experimental data. The datasets can be explored starting from some example queries (dementia mutations in MAPT, cystic fibrosis mutations in CFTR, cancer mutations in CTNNB1 phosphodegron), browsed interactively, downloaded in bulk or retrieved using an application program interface (API). Users can also upload their own custom datasets and store on the server for a limited time.

What's new?

This is a 2020 version of the ActiveDriverDB. Please see our changelog. To access the previous (2017) version click here. To access the newer (2021) version click here.

Example

Sequence

Network

TP53 (NM_000546)

Sequence | Network

PTPN11

Sequence | Network

TP53 mutations in cancer

Sequence | Network

Noonan syndrome mutations in PTPN11

Sequence | Network

About the data

Post-translational modifications (PTMs) are chemical modifications of amino acids that act as molecular switches and expand the functional repertoire of proteins. Genetic changes in the protein sequence, such as mis-sense single nucleotide variants (SNVs) collected in this database, often change the sequence and structure of sites corresponding to PTMs. Further, PTMs are created and erased by certain enzymes, such as kinases that cause protein phosphorylation. These enzymes recognize specific motifs in protein sequence that may also be changed by SNVs. Thus interpreting genetic variation with protein PTMs may reveal new mechanistic details of genetic variation and protein function and help decipher genotype-phenotype associations in human variation and disease.

You can browse gene and pathways, ranked by PTM mutations and/or FDR:

Alternatively, you can browse all genes or all pathways.

Proteins	39,159
Kinases and other PTM enzymes	655
Kinase families	143
Mutations ClinVar is hosted by the National Center for Biotechnology Information (NCBI), and is a freely accessible database of clinically significantly germilne and somatic variants. MC3 is the “Multi-Center Mutation Calling in Multiple Cancer” effort lead by The Cancer Genome Atlas (TCGA). The freely accessible MC3 dataset combines the independent mutation calling done by the Broad, Baylor, and/or Washington University. ESP6500 is part of the National Heart, Lung, and Blood Institute (NHLBI) Exome Sequencing Project (ESP), and is a multi-centre NGS project aimed at identifying new protein-coding regions associated with disorders affecting the blood, heart and lungs. 1000 Genomes is part of The International Genome Sample Resource (IGSR) effort to identify novel genetic variants in humans.	3,707,271
ClinVar	318,428
TCGA MC3	1,595,400
ESP6500	1,318,972
1000 Genomes	1,066,906
Mutations in PTM sites	826,828
Mutations network-rewiring effect (losses and gains of sequence motifs)	70,734
Total number of annotated nucleotides	96,138,347
Pathways	18,511
Kinase - site interactions	33,840
Kinases interacting with >= 1 site	497
PTM sites	544,720