TP53 Q144H

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Mutation:

Summary

Isoform:

NM_000546

Position:

144

Ref:

Mutation:

PTM impact:

distal

PTM affected:

Kinases:

CSNK2A1, CSNK2A1

Clinical Information

Cancer types: (TCGA MC3)

LUAD

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 139K

Affected site:

Position: 139

Residue: K

Type: ubiquitination

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
145P	KMFCQLAKTCPVQ[L/P]LW	6	distal
145Q	KMFCQLAKTCPVQ[L/Q]LW	6	distal
144H	KMFCQLAKTCPV[Q/H]QLW	5	distal
144L	KMFCQLAKTCPV[Q/L]QLW	5	distal
144P	KMFCQLAKTCPV[Q/P]QLW	5	distal
143G	KMFCQLAKTCP[V/G]VQLW	4	distal
143A	KMFCQLAKTCP[V/A]VQLW	4	distal
143L	KMFCQLAKTCP[V/L]VQLW	4	distal
143M	KMFCQLAKTCP[V/M]VQLW	4	distal
142L	KMFCQLAKTC[P/L]PVQLW	3	distal
142S	KMFCQLAKTC[P/S]PVQLW	3	distal
141W	KMFCQLAKT[C/W]CPVQLW	2	proximal
141F	KMFCQLAKT[C/F]CPVQLW	2	proximal
141Y	KMFCQLAKT[C/Y]CPVQLW	2	proximal
141G	KMFCQLAKT[C/G]CPVQLW	2	proximal
141R	KMFCQLAKT[C/R]CPVQLW	2	proximal
140N	KMFCQLAK[T/N]TCPVQLW	1	proximal
140A	KMFCQLAK[T/A]TCPVQLW	1	proximal
139N	KMFCQLA[K/N]KTCPVQLW	0	direct
139E	KMFCQLA[K/E]KTCPVQLW	0	direct
138V	KMFCQL[A/V]AKTCPVQLW	1	proximal
138D	KMFCQL[A/D]AKTCPVQLW	1	proximal
138P	KMFCQL[A/P]AKTCPVQLW	1	proximal
136H	KMFC[Q/H]QLAKTCPVQLW	3	distal
136P	KMFC[Q/P]QLAKTCPVQLW	3	distal
136E	KMFC[Q/E]QLAKTCPVQLW	3	distal
135W	KMF[C/W]CQLAKTCPVQLW	4	distal
135F	KMF[C/F]CQLAKTCPVQLW	4	distal
135Y	KMF[C/Y]CQLAKTCPVQLW	4	distal
135G	KMF[C/G]CQLAKTCPVQLW	4	distal
135R	KMF[C/R]CQLAKTCPVQLW	4	distal
135S	KMF[C/S]CQLAKTCPVQLW	4	distal
134C	KM[F/C]FCQLAKTCPVQLW	5	distal
134L	KM[F/L]FCQLAKTCPVQLW	5	distal
134I	KM[F/I]FCQLAKTCPVQLW	5	distal
143E	KMFCQLAKTCP[V/E]VQLW	4	distal
138T	KMFCQL[A/T]AKTCPVQLW	1	proximal
133K	K[M/K]MFCQLAKTCPVQLW	6	distal
145R	KMFCQLAKTCPVQ[L/R]LW	6	distal
134V	KM[F/V]FCQLAKTCPVQLW	5	distal
137Q	KMFCQ[L/Q]LAKTCPVQLW	2	proximal
133R	K[M/R]MFCQLAKTCPVQLW	6	distal

PTM Site: 149S

Affected site:

Position: 149

Residue: S

Type: O-glycosylation, phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
155S	PVQLWVDSTPPPG[T/S]TR	6	distal
155N	PVQLWVDSTPPPG[T/N]TR	6	distal
155A	PVQLWVDSTPPPG[T/A]TR	6	distal
154V	PVQLWVDSTPPP[G/V]GTR	5	distal
154D	PVQLWVDSTPPP[G/D]GTR	5	distal
154R	PVQLWVDSTPPP[G/R]GTR	5	distal
154S	PVQLWVDSTPPP[G/S]GTR	5	distal
153L	PVQLWVDSTPP[P/L]PGTR	4	distal
153S	PVQLWVDSTPP[P/S]PGTR	4	network-rewiring
152L	PVQLWVDSTP[P/L]PPGTR	3	distal
152R	PVQLWVDSTP[P/R]PPGTR	3	distal
152S	PVQLWVDSTP[P/S]PPGTR	3	distal
151R	PVQLWVDST[P/R]PPPGTR	2	network-rewiring
151H	PVQLWVDST[P/H]PPPGTR	2	proximal
151S	PVQLWVDST[P/S]PPPGTR	2	proximal
151A	PVQLWVDST[P/A]PPPGTR	2	proximal
151T	PVQLWVDST[P/T]PPPGTR	2	proximal
149F	PVQLWVD[S/F]STPPPGTR	0	direct
148A	PVQLWV[D/A]DSTPPPGTR	1	proximal
148Y	PVQLWV[D/Y]DSTPPPGTR	1	proximal
148N	PVQLWV[D/N]DSTPPPGTR	1	proximal
147A	PVQLW[V/A]VDSTPPPGTR	2	proximal
147I	PVQLW[V/I]VDSTPPPGTR	2	proximal
146C	PVQL[W/C]WVDSTPPPGTR	3	distal
146G	PVQL[W/G]WVDSTPPPGTR	3	distal
145P	PVQ[L/P]LWVDSTPPPGTR	4	distal
145Q	PVQ[L/Q]LWVDSTPPPGTR	4	distal
144H	PV[Q/H]QLWVDSTPPPGTR	5	distal
144L	PV[Q/L]QLWVDSTPPPGTR	5	distal
144P	PV[Q/P]QLWVDSTPPPGTR	5	distal
143G	P[V/G]VQLWVDSTPPPGTR	6	distal
143A	P[V/A]VQLWVDSTPPPGTR	6	distal
143L	P[V/L]VQLWVDSTPPPGTR	6	distal
143M	P[V/M]VQLWVDSTPPPGTR	6	distal
155I	PVQLWVDSTPPPG[T/I]TR	6	distal
155P	PVQLWVDSTPPPG[T/P]TR	6	distal
143E	P[V/E]VQLWVDSTPPPGTR	6	distal
152Q	PVQLWVDSTP[P/Q]PPGTR	3	distal
145R	PVQ[L/R]LWVDSTPPPGTR	4	distal
146S	PVQL[W/S]WVDSTPPPGTR	3	distal

PTM Site: 150T

Affected site:

Position: 150

Residue: T

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
156P	VQLWVDSTPPPGT[R/P]RV	6	distal
156H	VQLWVDSTPPPGT[R/H]RV	6	distal
156C	VQLWVDSTPPPGT[R/C]RV	6	distal
155S	VQLWVDSTPPPG[T/S]TRV	5	distal
155N	VQLWVDSTPPPG[T/N]TRV	5	distal
155A	VQLWVDSTPPPG[T/A]TRV	5	distal
154V	VQLWVDSTPPP[G/V]GTRV	4	distal
154D	VQLWVDSTPPP[G/D]GTRV	4	distal
154R	VQLWVDSTPPP[G/R]GTRV	4	distal
154S	VQLWVDSTPPP[G/S]GTRV	4	distal
153L	VQLWVDSTPP[P/L]PGTRV	3	distal
153S	VQLWVDSTPP[P/S]PGTRV	3	distal
152L	VQLWVDSTP[P/L]PPGTRV	2	proximal
152R	VQLWVDSTP[P/R]PPGTRV	2	network-rewiring
152S	VQLWVDSTP[P/S]PPGTRV	2	proximal
151R	VQLWVDST[P/R]PPPGTRV	1	network-rewiring
151H	VQLWVDST[P/H]PPPGTRV	1	network-rewiring
151S	VQLWVDST[P/S]PPPGTRV	1	network-rewiring
151A	VQLWVDST[P/A]PPPGTRV	1	network-rewiring
151T	VQLWVDST[P/T]PPPGTRV	1	network-rewiring
149F	VQLWVD[S/F]STPPPGTRV	1	proximal
148A	VQLWV[D/A]DSTPPPGTRV	2	proximal
148Y	VQLWV[D/Y]DSTPPPGTRV	2	proximal
148N	VQLWV[D/N]DSTPPPGTRV	2	proximal
147A	VQLW[V/A]VDSTPPPGTRV	3	distal
147I	VQLW[V/I]VDSTPPPGTRV	3	distal
146C	VQL[W/C]WVDSTPPPGTRV	4	distal
146G	VQL[W/G]WVDSTPPPGTRV	4	distal
145P	VQ[L/P]LWVDSTPPPGTRV	5	distal
145Q	VQ[L/Q]LWVDSTPPPGTRV	5	distal
144H	V[Q/H]QLWVDSTPPPGTRV	6	distal
144L	V[Q/L]QLWVDSTPPPGTRV	6	distal
144P	V[Q/P]QLWVDSTPPPGTRV	6	distal
155I	VQLWVDSTPPPG[T/I]TRV	5	distal
155P	VQLWVDSTPPPG[T/P]TRV	5	distal
156G	VQLWVDSTPPPGT[R/G]RV	6	distal
152Q	VQLWVDSTP[P/Q]PPGTRV	2	proximal
145R	VQ[L/R]LWVDSTPPPGTRV	5	distal
146S	VQL[W/S]WVDSTPPPGTRV	4	distal

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