You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
TP53 L145P
Summary
Isoform:
Position:
145
Ref:
L
Mutation:
P
PTM impact:
distal
PTM affected:
3
Kinases:
CSNK2A1,
CSNK2A1
Clinical Information
Cancer types: (TCGA MC3)
LGG, STAD
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Hereditary cancer-predisposing syndrome, Li-Fraumeni syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 139K
Affected site:
Position: 139
Residue: K
Type: ubiquitination
Impact:
distalOther known mutations affecting this site
Loading, please wait...
Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 139N | KMFCQLA[K/N]KTCPVQLW | 0 |
direct
|
| 139E | KMFCQLA[K/E]KTCPVQLW | 0 |
direct
|
| 140N | KMFCQLAK[T/N]TCPVQLW | 1 |
proximal
|
| 140A | KMFCQLAK[T/A]TCPVQLW | 1 |
proximal
|
| 138V | KMFCQL[A/V]AKTCPVQLW | 1 |
proximal
|
PTM Site: 149S
Affected site:
Position: 149
Residue: S
Type: O-glycosylation, phosphorylation
Impact:
distalOther known mutations affecting this site
Loading, please wait...
Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 149F | PVQLWVD[S/F]STPPPGTR | 0 |
direct
|
| 148A | PVQLWV[D/A]DSTPPPGTR | 1 |
proximal
|
| 148Y | PVQLWV[D/Y]DSTPPPGTR | 1 |
proximal
|
| 148N | PVQLWV[D/N]DSTPPPGTR | 1 |
proximal
|
| 151R | PVQLWVDST[P/R]PPPGTR | 2 |
network-rewiring
|
PTM Site: 150T
Affected site:
Position: 150
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
Loading, please wait...
Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 151R | VQLWVDST[P/R]PPPGTRV | 1 |
network-rewiring
|
| 151H | VQLWVDST[P/H]PPPGTRV | 1 |
network-rewiring
|
| 151S | VQLWVDST[P/S]PPPGTRV | 1 |
network-rewiring
|
| 151A | VQLWVDST[P/A]PPPGTRV | 1 |
network-rewiring
|
| 151T | VQLWVDST[P/T]PPPGTRV | 1 |
network-rewiring
|
External references
dbSNP:
If you have any questions or feedback about this mutation:
Contact us