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Mutation:
TP53 R156P
Summary
Isoform:
Position:
156
Ref:
R
Mutation:
P
PTM impact:
network-rewiring
PTM affected:
3
Kinases:
CSNK2A1,
CSNK2A1,
CSNK2A1
Clinical Information
Cancer types: (TCGA MC3)
LUAD, HNSC, LIHC, BLCA
Cancer types: (PCAWG)
Ovary-AdenoCA
Disease Annotations: (ClinVar)
Hereditary cancer-predisposing syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 149S
Affected site:
Position: 149
Residue: S
Type: phosphorylation, O-glycosylation
Impact:
distalOther known mutations affecting this site
PTM Site: 150T
Affected site:
Position: 150
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
PTM Site: 155T
Affected site:
Position: 155
Residue: T
Type: phosphorylation
Best gain of PTM site:
MAPK14 (probability p=0.993)
Site: 155T (phosphorylation)
Position in motif: 1
There are 10 other predicted
gains:
- MAPK12 (p=0.96)
- MAPK3 (p=0.959)
- MAPK8 (p=0.933)
- GSK3B (p=0.931)
- MTOR (p=0.927)
- MAPK7 (p=0.926)
- CDK2 (p=0.922)
- HIPK2 (p=0.922)
- MAPK9 (p=0.918)
- CDK7 (p=0.877)
Other known mutations affecting this site
External references
dbSNP:
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