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You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:

TP53 P151R

Summary

Isoform:
NM_000546
Position:
151
Ref:
P
Mutation:
R
PTM impact:
network-rewiring
PTM affected:
3
Kinases:
CSNK2A1, CSNK2A1, CSNK2A1

Clinical Information

Cancer types: (TCGA MC3)

LUSC, PAAD, UCS

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

Li-Fraumeni syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 149S

Affected site:

Position: 149
Residue: S
Type: O-glycosylation, phosphorylation

Only gain of PTM site:

PRKCG (probability p=0.855)
Site: 149S (phosphorylation, O-glycosylation)
Position in motif: 2

Best loss of PTM site:

MAPK3 (probability p=0.94)
Site: 150T (phosphorylation)
Position in motif: 1
There are 6 other predicted losses:
  • CDK1 (p=0.921)
  • MAPK1 (p=0.92)
  • GSK3B (p=0.887)
  • CDK4 (p=0.881)
  • CDK7 (p=0.877)
  • CDK2 (p=0.872)

Other known mutations affecting this site

Mutation In sequence Distance Impact
155S PVQLWVDSTPPPG[T/S]TR 6
distal
155N PVQLWVDSTPPPG[T/N]TR 6
distal
155A PVQLWVDSTPPPG[T/A]TR 6
distal
154V PVQLWVDSTPPP[G/V]GTR 5
distal
154D PVQLWVDSTPPP[G/D]GTR 5
distal
154R PVQLWVDSTPPP[G/R]GTR 5
distal
154S PVQLWVDSTPPP[G/S]GTR 5
distal
153L PVQLWVDSTPP[P/L]PGTR 4
distal
153S PVQLWVDSTPP[P/S]PGTR 4
network-rewiring
152L PVQLWVDSTP[P/L]PPGTR 3
distal
152R PVQLWVDSTP[P/R]PPGTR 3
distal
152S PVQLWVDSTP[P/S]PPGTR 3
distal
151R PVQLWVDST[P/R]PPPGTR 2
network-rewiring
151H PVQLWVDST[P/H]PPPGTR 2
proximal
151S PVQLWVDST[P/S]PPPGTR 2
proximal
151A PVQLWVDST[P/A]PPPGTR 2
proximal
151T PVQLWVDST[P/T]PPPGTR 2
proximal
149F PVQLWVD[S/F]STPPPGTR 0
direct
148A PVQLWV[D/A]DSTPPPGTR 1
proximal
148Y PVQLWV[D/Y]DSTPPPGTR 1
proximal
148N PVQLWV[D/N]DSTPPPGTR 1
proximal
147A PVQLW[V/A]VDSTPPPGTR 2
proximal
147I PVQLW[V/I]VDSTPPPGTR 2
proximal
146C PVQL[W/C]WVDSTPPPGTR 3
distal
146G PVQL[W/G]WVDSTPPPGTR 3
distal
145P PVQ[L/P]LWVDSTPPPGTR 4
distal
145Q PVQ[L/Q]LWVDSTPPPGTR 4
distal
144H PV[Q/H]QLWVDSTPPPGTR 5
distal
144L PV[Q/L]QLWVDSTPPPGTR 5
distal
144P PV[Q/P]QLWVDSTPPPGTR 5
distal
143G P[V/G]VQLWVDSTPPPGTR 6
distal
143A P[V/A]VQLWVDSTPPPGTR 6
distal
143L P[V/L]VQLWVDSTPPPGTR 6
distal
143M P[V/M]VQLWVDSTPPPGTR 6
distal
155I PVQLWVDSTPPPG[T/I]TR 6
distal
155P PVQLWVDSTPPPG[T/P]TR 6
distal
143E P[V/E]VQLWVDSTPPPGTR 6
distal
152Q PVQLWVDSTP[P/Q]PPGTR 3
distal
145R PVQ[L/R]LWVDSTPPPGTR 4
distal
146S PVQL[W/S]WVDSTPPPGTR 3
distal

PTM Site: 150T

Affected site:

Position: 150
Residue: T
Type: phosphorylation

Only gain of PTM site:

PRKCG (probability p=0.855)
Site: 149S (phosphorylation, O-glycosylation)
Position in motif: 2

Best loss of PTM site:

MAPK3 (probability p=0.94)
Site: 150T (phosphorylation)
Position in motif: 1
There are 6 other predicted losses:
  • CDK1 (p=0.921)
  • MAPK1 (p=0.92)
  • GSK3B (p=0.887)
  • CDK4 (p=0.881)
  • CDK7 (p=0.877)
  • CDK2 (p=0.872)

Other known mutations affecting this site

Mutation In sequence Distance Impact
156P VQLWVDSTPPPGT[R/P]RV 6
distal
156H VQLWVDSTPPPGT[R/H]RV 6
distal
156C VQLWVDSTPPPGT[R/C]RV 6
distal
155S VQLWVDSTPPPG[T/S]TRV 5
distal
155N VQLWVDSTPPPG[T/N]TRV 5
distal
155A VQLWVDSTPPPG[T/A]TRV 5
distal
154V VQLWVDSTPPP[G/V]GTRV 4
distal
154D VQLWVDSTPPP[G/D]GTRV 4
distal
154R VQLWVDSTPPP[G/R]GTRV 4
distal
154S VQLWVDSTPPP[G/S]GTRV 4
distal
153L VQLWVDSTPP[P/L]PGTRV 3
distal
153S VQLWVDSTPP[P/S]PGTRV 3
distal
152L VQLWVDSTP[P/L]PPGTRV 2
proximal
152R VQLWVDSTP[P/R]PPGTRV 2
network-rewiring
152S VQLWVDSTP[P/S]PPGTRV 2
proximal
151R VQLWVDST[P/R]PPPGTRV 1
network-rewiring
151H VQLWVDST[P/H]PPPGTRV 1
network-rewiring
151S VQLWVDST[P/S]PPPGTRV 1
network-rewiring
151A VQLWVDST[P/A]PPPGTRV 1
network-rewiring
151T VQLWVDST[P/T]PPPGTRV 1
network-rewiring
149F VQLWVD[S/F]STPPPGTRV 1
proximal
148A VQLWV[D/A]DSTPPPGTRV 2
proximal
148Y VQLWV[D/Y]DSTPPPGTRV 2
proximal
148N VQLWV[D/N]DSTPPPGTRV 2
proximal
147A VQLW[V/A]VDSTPPPGTRV 3
distal
147I VQLW[V/I]VDSTPPPGTRV 3
distal
146C VQL[W/C]WVDSTPPPGTRV 4
distal
146G VQL[W/G]WVDSTPPPGTRV 4
distal
145P VQ[L/P]LWVDSTPPPGTRV 5
distal
145Q VQ[L/Q]LWVDSTPPPGTRV 5
distal
144H V[Q/H]QLWVDSTPPPGTRV 6
distal
144L V[Q/L]QLWVDSTPPPGTRV 6
distal
144P V[Q/P]QLWVDSTPPPGTRV 6
distal
155I VQLWVDSTPPPG[T/I]TRV 5
distal
155P VQLWVDSTPPPG[T/P]TRV 5
distal
156G VQLWVDSTPPPGT[R/G]RV 6
distal
152Q VQLWVDSTP[P/Q]PPGTRV 2
proximal
145R VQ[L/R]LWVDSTPPPGTRV 5
distal
146S VQL[W/S]WVDSTPPPGTRV 4
distal

PTM Site: 155T

Affected site:

Position: 155
Residue: T
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
161D DSTPPPGTRVRAM[A/D]AI 6
distal
161T DSTPPPGTRVRAM[A/T]AI 6
distal
159V DSTPPPGTRVR[A/V]AMAI 4
distal
159P DSTPPPGTRVR[A/P]AMAI 4
distal
158L DSTPPPGTRV[R/L]RAMAI 3
distal
158P DSTPPPGTRV[R/P]RAMAI 3
distal
158H DSTPPPGTRV[R/H]RAMAI 3
distal
158C DSTPPPGTRV[R/C]RAMAI 3
distal
158G DSTPPPGTRV[R/G]RAMAI 3
distal
157G DSTPPPGTR[V/G]VRAMAI 2
proximal
157A DSTPPPGTR[V/A]VRAMAI 2
proximal
157D DSTPPPGTR[V/D]VRAMAI 2
proximal
157F DSTPPPGTR[V/F]VRAMAI 2
proximal
157I DSTPPPGTR[V/I]VRAMAI 2
proximal
156P DSTPPPGT[R/P]RVRAMAI 1
network-rewiring
156H DSTPPPGT[R/H]RVRAMAI 1
proximal
156C DSTPPPGT[R/C]RVRAMAI 1
proximal
155S DSTPPPG[T/S]TRVRAMAI 0
direct
155N DSTPPPG[T/N]TRVRAMAI 0
direct
155A DSTPPPG[T/A]TRVRAMAI 0
direct
154V DSTPPP[G/V]GTRVRAMAI 1
proximal
154D DSTPPP[G/D]GTRVRAMAI 1
proximal
154R DSTPPP[G/R]GTRVRAMAI 1
proximal
154S DSTPPP[G/S]GTRVRAMAI 1
proximal
153L DSTPP[P/L]PGTRVRAMAI 2
proximal
153S DSTPP[P/S]PGTRVRAMAI 2
proximal
152L DSTP[P/L]PPGTRVRAMAI 3
distal
152R DSTP[P/R]PPGTRVRAMAI 3
network-rewiring
152S DSTP[P/S]PPGTRVRAMAI 3
distal
151R DST[P/R]PPPGTRVRAMAI 4
distal
151H DST[P/H]PPPGTRVRAMAI 4
distal
151S DST[P/S]PPPGTRVRAMAI 4
distal
151A DST[P/A]PPPGTRVRAMAI 4
distal
151T DST[P/T]PPPGTRVRAMAI 4
distal
149F D[S/F]STPPPGTRVRAMAI 6
distal
155I DSTPPPG[T/I]TRVRAMAI 0
direct
155P DSTPPPG[T/P]TRVRAMAI 0
direct
156G DSTPPPGT[R/G]RVRAMAI 1
proximal
157L DSTPPPGTR[V/L]VRAMAI 2
proximal
161V DSTPPPGTRVRAM[A/V]AI 6
distal
152Q DSTP[P/Q]PPGTRVRAMAI 3
distal
161S DSTPPPGTRVRAM[A/S]AI 6
distal
160I DSTPPPGTRVRA[M/I]MAI 5
distal
161P DSTPPPGTRVRAM[A/P]AI 6
distal
158S DSTPPPGTRV[R/S]RAMAI 3
network-rewiring

External references

dbSNP:
rs1057520000

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