You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
TP53 P151H
Summary
Isoform:
Position:
151
Ref:
P
Mutation:
H
PTM impact:
network-rewiring
PTM affected:
3
Kinases:
CSNK2A1,
CSNK2A1,
CSNK2A1
Clinical Information
Cancer types: (TCGA MC3)
LIHC, BRCA, HNSC, BLCA, ESCA
Cancer types: (PCAWG)
ColoRect-AdenoCA
Disease Annotations: (ClinVar)
Li-Fraumeni syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 149S
Affected site:
Position: 149
Residue: S
Type: O-glycosylation, phosphorylation
Impact:
proximalOther known mutations affecting this site
PTM Site: 150T
Affected site:
Position: 150
Residue: T
Type: phosphorylation
Best loss of PTM site:
MAPK3 (probability p=0.94)
Site: 150T (phosphorylation)
Position in motif: 1
There are 5 other predicted
losses:
- CDK1 (p=0.921)
- MAPK1 (p=0.92)
- GSK3B (p=0.887)
- CDK4 (p=0.881)
- CDK2 (p=0.872)
Other known mutations affecting this site
PTM Site: 155T
Affected site:
Position: 155
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
External references
dbSNP:
If you have any questions or feedback about this mutation:
Contact us